Proteintech

NPPA Polyclonal Antibody

NPPA Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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NPPA Antibody (27426-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human heart tissue slide using 27426-1-AP ( NPPA antibody) at dilution of 1:200 (under 40x lens).

Product Image Gallery

Product Details

27426-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 17 publications 17 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

ELISA (ELISA)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

NPPA Fusion Protein Ag26692 (26-153 aa encoded by BC005893)

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.33 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: NPMYNAVSN ADLMDFKNLL DHLEEKMPLE DEVVPPQVLS EPNEEAGAAL SPLPEVPPWT GEVSPAQRDG GALGRGPWDS SDRSALLKSK LRALLTAPRS LRRSSCFGGR MDRIGAQSGL GCNSFRYRR (26-153 aa encoded by BC005893)

Target Information

The protein encoded by this gene belongs to the natriuretic peptide family. Natriuretic peptides are implicated in the control of extracellular fluid volume and electrolyte homeostasis. This protein is synthesized as a large precursor (containing a signal peptide), which is processed to release a peptide from the N-terminus with similarity to vasoactive peptide, cardiodilatin, and another peptide from the C-terminus with natriuretic-diuretic activity. Mutations in this gene have been associated with atrial fibrillation familial type 6.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Exploring novel biomarkers in dilated cardiomyopathy‑induced heart failure by integrated analysis and in vitro experiments.

Experimental and therapeutic medicine

Zhou L,Peng F,Li J,Gong H

Sat Jul 01 00:00:00 EDT 2023

Soluble epoxide hydrolase and TRPC3 channels jointly contribute to homocysteine-induced cardiac hypertrophy: Interrelation and regulation by C/EBPβ.

Biochimica et biophysica acta. Molecular basis of disease

Zhou Y,Wang XC,Wei JH,Xue HM,Sun WT,He GW,Yang Q

Sat Apr 01 00:00:00 EDT 2023

GLUT4 mediates the protective function of gastrodin against pressure overload-induced cardiac hypertrophy.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Zhang M,Tan Y,Song Y,Zhu M,Zhang B,Chen C,Liu Y,Shi L,Cui J,Shan W,Jia Z,Feng L,Cao G,Yi W,Sun Y

Mon May 01 00:00:00 EDT 2023

Chronic β-adrenergic stress contributes to cardiomyopathy in rodents with collagen-induced arthritis.

Acta pharmacologica Sinica

Zhu ZD,Zhang M,Wang Z,Jiang CR,Huang CJ,Cheng HJ,Guan QY,Su TT,Wang MM,Gao Y,Wu HF,Wei W,Han YS,Wang QT

Sun Oct 01 00:00:00 EDT 2023

G9a inhibition promotes the formation of pacemaker-like cells by reducing the enrichment of H3K9me2 in the HCN4 promoter region.

Molecular medicine reports

Xu P,Jin K,Zhou J,Gu J,Gu X,Dong L,Sun X

Wed Feb 01 00:00:00 EST 2023

Metformin Collaborates with PINK1/Mfn2 Overexpression to Prevent Cardiac Injury by Improving Mitochondrial Function.

Biology

Ma Z,Liu Z,Li X,Zhang H,Han D,Xiong W,Zhou H,Yang X,Zeng Q,Ren H,Xu D

Tue Apr 11 00:00:00 EDT 2023

HypERlnc attenuates angiotensin II-induced cardiomyocyte hypertrophy via promoting SIRT1 SUMOylation-mediated activation of PGC-1α/PPARα pathway in AC16 cells.

Cell biology international

Yue L,Sheng S,Yuan M,Lu J,Li T,Shi Y,Dong Z

Thu Jun 01 00:00:00 EDT 2023

Trim65 attenuates isoproterenol-induced cardiac hypertrophy by promoting autophagy and ameliorating mitochondrial dysfunction via the Jak1/Stat1 signaling pathway.

European journal of pharmacology

Liu H,Zhou Z,Deng H,Tian Z,Wu Z,Liu X,Ren Z,Jiang Z

Thu Jun 15 00:00:00 EDT 2023

Trim65 attenuates isoproterenol-induced cardiac hypertrophy by promoting autophagy and ameliorating mitochondrial dysfunction via the Jak1/Stat1 signaling pathway.

European journal of pharmacology

Liu H,Zhou Z,Deng H,Tian Z,Wu Z,Liu X,Ren Z,Jiang Z

Thu Jun 15 00:00:00 EDT 2023

Trim65 attenuates isoproterenol-induced cardiac hypertrophy by promoting autophagy and ameliorating mitochondrial dysfunction via the Jak1/Stat1 signaling pathway.

European journal of pharmacology

Liu H,Zhou Z,Deng H,Tian Z,Wu Z,Liu X,Ren Z,Jiang Z

Thu Jun 15 00:00:00 EDT 2023

Trim65 attenuates isoproterenol-induced cardiac hypertrophy by promoting autophagy and ameliorating mitochondrial dysfunction via the Jak1/Stat1 signaling pathway.

European journal of pharmacology

Liu H,Zhou Z,Deng H,Tian Z,Wu Z,Liu X,Ren Z,Jiang Z

Thu Jun 15 00:00:00 EDT 2023

Transient Receptor Potential Vanilloid Type 1 Protects Against Pressure Overload-Induced Cardiac Hypertrophy by Promoting Mitochondria-Associated Endoplasmic Reticulum Membranes.

Journal of cardiovascular pharmacology

Wang Y,Li X,Xu X,Qu X,Yang Y

Thu Sep 01 00:00:00 EDT 2022

Cullin-associated and neddylation-dissociated 1 protein (CAND1) governs cardiac hypertrophy and heart failure partially through regulating calcineurin degradation.

Pharmacological research

Li X,Zhang Y,Zhao Y,Zhou Y,Han Q,Yang Y,Zhang L,Shi L,Jin X,Zhang R,Gao H,Xue G,Li D,Zhang ZR,Lu Y,Yang B,Pan Z

Mon Aug 01 00:00:00 EDT 2022

SUMOylation of SIRT1 activating PGC-1α/PPARα pathway mediates the protective effect of LncRNA-MHRT in cardiac hypertrophy.

European journal of pharmacology

Liu MY,Yue LJ,Luo YC,Lu J,Wu GD,Sheng SQ,Shi YQ,Dong ZX

Mon Sep 05 00:00:00 EDT 2022

Overexpression of cytosolic long noncoding RNA cytb protects against pressure-overload-induced heart failure via sponging microRNA-103-3p.

Molecular therapy. Nucleic acids

Zhang X,Yuan S,Liu J,Tang Y,Wang Y,Zhan J,Fan J,Nie X,Zhao Y,Wen Z,Li H,Chen C,Wang DW

Tue Mar 08 00:00:00 EST 2022

regulates pathological cardiac hypertrophy via a β-catenin-dependent mechanism.

American journal of physiology. Heart and circulatory physiology

Lin L,Xu W,Li Y,Zhu P,Yuan W,Liu M,Shi Y,Chen Y,Liang J,Chen J,Yang B,Cai W,Wen Y,Zhu X,Peng X,Zhou Z,Mo X,Wan Y,Yuan H,Li F,Ye X,Jiang Z,Wang Y,Zhuang J,Fan X,Wu X

Thu Apr 01 00:00:00 EDT 2021

CBL aggravates Ang II-induced cardiac hypertrophy via the VHL/HIF-1α pathway.

Experimental cell research

Yang Y,Zou P,He L,Shao J,Tang Y,Li J

Sun Aug 15 00:00:00 EDT 2021

Gastrodin Exerts Cardioprotective Action via Inhibition of Insulin-Like Growth Factor Type 2/Insulin-Like Growth Factor Type 2 Receptor Expression in Cardiac Hypertrophy.

ACS omega

Lu J,Ma X,Gao WC,Zhang X,Fu Y,Liu Q,Tian L,Qin XD,Yang W,Zheng HY,Zheng CB

Tue Jul 06 00:00:00 EDT 2021

Examination of the Effect of a 50-Hz Electromagnetic Field at 500 μT on Parameters Related With the Cardiovascular System in Rats.

Frontiers in public health

Zhang Y,Li L,Liu X,Ding L,Wu X,Wang J,He M,Hou H,Ruan G,Lai J,Chen C

Fri May 14 00:00:00 EDT 2021

Ranolazine prevents pressure overload-induced cardiac hypertrophy and heart failure by restoring aberrant Na⁺ and Ca²⁺ handling.

Journal of cellular physiology

Nie J,Duan Q,He M,Li X,Wang B,Zhou C,Wu L,Wen Z,Chen C,Wang DW,Alsina KM,Wehrens XHT,Wang DW,Ni L

Mon Jul 01 00:00:00 EDT 2019

Ranolazine prevents pressure overload-induced cardiac hypertrophy and heart failure by restoring aberrant Na⁺ and Ca²⁺ handling.

Journal of cellular physiology

Nie J,Duan Q,He M,Li X,Wang B,Zhou C,Wu L,Wen Z,Chen C,Wang DW,Alsina KM,Wehrens XHT,Wang DW,Ni L

Mon Jul 01 00:00:00 EDT 2019

Bioinformatics

Protein Aliases: atrial natriuretic factor; Atrial natriuretic factor prohormone; atrial natriuretic peptide; Atrial natriuretic peptide prohormone; Atriopeptigen; atriopeptin; Cardiodilatin; cardiodilatin-related peptide; cardionatrin; CDD; Natriuretic peptide precursor A (pronatriodilatin, also Anf, Pnd); natriuretic peptide precursor A variant 1; natriuretic peptide precursor A variant NPPA-M1; natriuretic peptide precursor A variant NPPA-M2; natriuretic peptide precursor A variant NPPA-M3; natriuretic peptide precursor type A; Natriuretic peptides A; preproANF; preproANP; preproCDD-ANF; prepronatriodilatin; proANF; Pronatriodilatin; urodilatin

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Gene Aliases: ANF; ANP; ATFB6; ATRST2; CDD; CDD-ANF; CDP; NPPA; PND; RATANF

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UniProt ID: (Human) P01160, (Rat) P01161, (Mouse) P05125

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Entrez Gene ID: (Human) 4878, (Rat) 24602, (Mouse) 230899

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Function(s)

receptor binding neuropeptide hormone activity protein binding peptide hormone receptor binding neuropeptide receptor binding hormone activity

Process(es)

response to hypoxia negative regulation of systemic arterial blood pressure cGMP biosynthetic process transcription initiation from RNA polymerase II promoter receptor guanylyl cyclase signaling pathway neuropeptide signaling pathway female pregnancy regulation of blood pressure positive regulation of heart rate cardiac muscle hypertrophy in response to stress negative regulation of cell growth response to insulin response to muscle stretch cellular protein metabolic process regulation of blood vessel size regulation of atrial cardiac muscle cell membrane repolarization positive regulation of cardiac muscle contraction cell growth involved in cardiac muscle cell development cellular response to mechanical stimulus regulation of high voltage-gated calcium channel activity positive regulation of delayed rectifier potassium channel activity regulation of calcium ion transmembrane transport via high voltage-gated calcium channel positive regulation of potassium ion export across plasma membrane regulation of cardiac conduction negative regulation of collecting lymphatic vessel constriction heart development regulation of body fluid levels multicellular organismal water homeostasis

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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NPPA Polyclonal Antibody

NPPA Antibody (27426-1-AP) in IHC (P)

Product Details

27426-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

ELISA (ELISA)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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