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Product Details
PA5-50486
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to a region derived from internal residues of human Natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)
Conjugate
Form
Liquid
Concentration
1.3 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 40% glycerol
Contains
0.05% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2635939
Product Specific Information
The antibody detects endogenous levels of total NPR1 protein.
Target Information
Guanylyl cyclases, catalyzing the production of cGMP from GTP, are classified as soluble and membrane forms. The membrane guanylyl cyclases, often termed guanylyl cyclases A through F, form a family of cell-surface receptors with a similar topographic structure: an extracellular ligand-binding domain, a single membrane-spanning domain, and an intracellular region that contains a protein kinase-like domain and a cyclase catalytic domain. GC-A and GC-B function as receptors for natriuretic peptides; they are also referred to as atrial natriuretic peptide receptor A and type B. Also see NPR3, which encodes a protein with only the ligand-binding transmembrane and 37-amino acid cytoplasmic domains. NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides and BNP, respectively).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ANP-A; ANPR-A; atrial natriuretic peptide A-type receptor; Atrial natriuretic peptide receptor 1; atrial natriuretic peptide receptor A; Atrial natriuretic peptide receptor type A; atrionatriuretic peptide receptor A; GC-A; Guanylate cyclase A; guanylyl cyclase-A; natriuretic peptide A type receptor; natriuretic peptide receptor A; natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A); Nppa receptor; NPR-A; testicular tissue protein Li 20
Gene Aliases: AI893888; ANPa; ANPRA; GC-A; Gca; GUC2A; GUCY2A; NPR-A; NPR1; NPRA; Pndr
UniProt ID: (Human) P16066, (Mouse) P18293, (Rat) P18910
Entrez Gene ID: (Human) 4881, (Mouse) 18160, (Rat) 24603
adenylate cyclase activity
guanylate cyclase activity
protein kinase activity
ATP binding
GTP binding
G-protein coupled peptide receptor activity
natriuretic peptide receptor activity
peptide hormone binding
protein kinase binding
hormone binding
nucleotide binding
transferase activity, transferring phosphorus-containing groups
lyase activity
phosphorus-oxygen lyase activity
protein binding
guanylate cyclase
cGMP biosynthetic process
protein phosphorylation
cell surface receptor signaling pathway
receptor guanylyl cyclase signaling pathway
G-protein coupled receptor signaling pathway
body fluid secretion
regulation of blood pressure
negative regulation of angiogenesis
negative regulation of cell growth
positive regulation of cGMP biosynthetic process
intracellular signal transduction
positive regulation of urine volume
positive regulation of renal sodium excretion
regulation of vasodilation
dopamine metabolic process
regulation of vascular permeability
negative regulation of smooth muscle cell proliferation
regulation of cardiac conduction
cyclic nucleotide biosynthetic process
regulation of blood vessel size
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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