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NPR3 Antibody (PA5-15394) in ICC/IF
Immunocytochemistry analysis of NPR3 in HeLa cells. Samples were incubated with NPR3 polyclonal antibody (Product # PA5-15394) using a dilution of 1:200 for 2 h at room temperature followed by Alexa Fluor® 488 conjugated donkey anti-rabbit at a dilution of 1:1,000 for 1hr. Cells were fixed with 4% PFA (20 min) and permeabilized with Triton X-100 (0.2%, 30 min). Nuclei were counterstained with Hoechst 33342 (blue) (10 µg/mL, 5 min). Note the highly specific localization of the Natriuretic Peptide Receptor C mainly to the mainly to the nucle... View More
Product Details
PA5-15394
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 67-97 amino acids from the N-terminal region of human Natriuretic Peptide Receptor C
Conjugate
Form
Liquid
Concentration
1.9 mg/mL
Purification
Ammonium sulfate precipitation
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2267531
Target Information
This gene encodes one of three natriuretic peptide receptors. Natriutetic peptides are small peptides which regulate blood volume and pressure, pulmonary hypertension, and cardiac function as well as some metabolic and growth processes. The product of this gene encodes a natriuretic peptide receptor responsible for clearing circulating and extracellular natriuretic peptides through endocytosis of the receptor. Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: A NPR-C; ANP-C; Atrial natriuretic peptide clearance receptor; Atrial natriuretic peptide receptor 3; Atrial natriuretic peptide receptor type C; atrionatriuretic peptide receptor C; guanylate cyclase C; natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)
Gene Aliases: ANP-C; ANPR-C; ANPRC; C5orf23; GUCY2B; NPR-C; NPR3; NPRC
UniProt ID: (Human) P17342
Entrez Gene ID: (Human) 4883
skeletal system development
osteoclast proliferation
cAMP biosynthetic process
adenylate cyclase-activating G-protein coupled receptor signaling pathway
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
regulation of blood pressure
cyclic nucleotide biosynthetic process
cAMP-mediated signaling
pancreatic juice secretion
regulation of osteoblast proliferation
positive regulation of urine volume
phosphatidylinositol-mediated signaling
negative regulation of smooth muscle cell proliferation
positive regulation of nitric-oxide synthase activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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