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Product Details
H00004899-M02
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
1B9
Immunogen
NRF1 (NP_005002, 201 a.a. approximately 285 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Product may be used with Western Blot (Transfected lysate).
Immunogen sequence: TQAQLRAFIP EMLKYSTGRG KPGWGKESCK PIWWPEDIPW ANVRSDVRTE EQKQRVSWTQ ALRTIVKNCY KQHGREDLLY AFEDQ
Target Information
This gene encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. The protein has also been associated with the regulation of neurite outgrowth. Alternate transcriptional splice variants, which encode the same protein, have been characterized. Additional variants encoding different protein isoforms have been described but they have not been fully characterized. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene and for "nuclear factor (erythroid-derived 2)-like 1" which has an official symbol of NFE2L1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Alpha palindromic-binding protein; Alpha-pal; EWG; NRF-1; Nuclear respiratory factor 1
Gene Aliases: ALPHA-PAL; NRF1
UniProt ID: (Human) Q16656
Entrez Gene ID: (Human) 4899
RNA polymerase II core promoter proximal region sequence-specific DNA binding
core promoter sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
protein binding
protein homodimerization activity
DNA-binding transcription factor
response to hypoxia
generation of precursor metabolites and energy
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
mitochondrion organization
organ regeneration
response to estradiol
response to lipopolysaccharide
positive regulation of transcription from RNA polymerase II promoter
response to folic acid
response to electrical stimulus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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