Proteintech

NRF1/nuclear respiratory factor 1 Polyclonal Antibody

NRF1/nuclear respiratory factor 1 Antibody in Western Blot (WB)

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NRF1/nuclear respiratory factor 1 Antibody (12482-1-AP) in WB

A431 cells were subjected to SDS PAGE followed by western blot with (Product # 12482-1-AP) NRF1/nuclear respiratory factor 1 antibody at dilution of 1:600 incubated at room temperature for 1.5 hours.

NRF1/nuclear respiratory factor 1 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

12482-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:3,000

View 59 publications 59 publications

Immunoprecipitation (IP)

1:300

Miscellaneous PubMed (Misc)

View 1 publication 1 publication

Not applicable (N/A)

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Goat, Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

NRF1/nuclear respiratory factor 1 Fusion Protein Ag3172 (213-522 aa encoded by BC016925)

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.19 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: LKYSTGRGK PGWGKESCKP IWWPEDIPWA NVRSDVRTEE QKQRVSWTQA LRTIVKNCYK QHGREDLLYA FEDQQTQTQA TATHSIAHLV PSQTVVQTFS NPDGTVSLIQ VGTGATVATL ADASELPTTV TVAQVNYSAV ADGEVEQNWA TLQGGEMTIQ TTQASEATQA VASLAEAAVA ASQEMQQGAT VTMALNSEAA AHAVATLAEA TLQGGGQIVL SGETAAAVGA LTGVQDANGL FMADRAGRKW ILTDKATGLV QIPVSMYQTV VTSLAQGNGP VQVAMAPVTT RISDSAVTMD GQAVEVVTLE Q (213-522 aa encoded by BC016925)

Target Information

This gene encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. The protein has also been associated with the regulation of neurite outgrowth. Alternate transcriptional splice variants, which encode the same protein, have been characterized. Additional variants encoding different protein isoforms have been described but they have not been fully characterized. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene and for "nuclear factor (erythroid-derived 2)-like 1" which has an official symbol of NFE2L1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Alpha palindromic-binding protein; Alpha-pal; EWG; NRF-1; Nuclear respiratory factor 1; nuclear respiratory factor-1

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Gene Aliases: ALPHA-PAL; C87038; D6Ertd415e; Nfe2l1_retired; NRF1

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UniProt ID: (Human) Q16656, (Mouse) Q9WU00

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Entrez Gene ID: (Human) 4899, (Rat) 312195, (Mouse) 18181

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Function(s)

RNA polymerase II core promoter proximal region sequence-specific DNA binding core promoter sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding protein binding protein homodimerization activity molecular_function DNA binding transcription factor activity, sequence-specific DNA binding DNA-binding transcription factor

Process(es)

response to hypoxia generation of precursor metabolites and energy regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter mitochondrion organization organ regeneration response to estradiol response to lipopolysaccharide positive regulation of transcription from RNA polymerase II promoter response to folic acid response to electrical stimulus transcription, DNA-templated regulation of transcription, DNA-templated

Performance Guarantee

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NRF1/nuclear respiratory factor 1 Polyclonal Antibody

NRF1/nuclear respiratory factor 1 Antibody (12482-1-AP) in WB

Product Details

12482-1-AP

Western Blot (WB)

Immunoprecipitation (IP)

Miscellaneous PubMed (Misc)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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