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Product Details
MA5-30715
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
005
Immunogen
Recombinant Human NRG1 Protein (Ser20-Lys241)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2786406
Product Specific Information
This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%).
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
This antibody has specificity for Human NRG1.
Target Information
Neuregulin 1 (NRG1) was originally identified as a 44-kD glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. It is known that an extraordinary variety of different isoforms are produced from the NRG1 gene by alternative splicing. These isoforms include heregulins (HRGs), glial growth factors (GGFs) and sensory and motor neuron-derived factor (SMDF). They are tissue-specifically expressed and differ significantly in their structure. The HRG isoforms all contain immunoglobulin (Ig) and epidermal growth factor-like (EGF-like) domains. GGF and GGF2 isoforms contain a kringle-like sequence plus Ig and EGF-like domains; and the SMDF isoform shares only the EGF-like domain with other isoforms. The receptors for all NRG1 isoforms are the ERBB family of tyrosine kinase transmembrane receptors. Through interaction with ERBB receptors, NRG1 isoforms induce the growth and differentiation of epithelial, neuronal, glial, and other types of cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: acetylcholine receptor-inducing activity; glial growth factor 2; heregulin, alpha (45kD, ERBB2 p185-activator); neu differentiation factor; Pro-neuregulin-1, membrane-bound isoform; Pro-NRG1; sensory and motor neuron derived factor
Gene Aliases: ARIA; GGF; GGF2; HGL; HRG; HRG1; HRGA; MST131; MSTP131; NDF; NRG1; NRG1-IT2; SMDF
UniProt ID: (Human) A5YAK4
Entrez Gene ID: (Human) 3084
transcription cofactor activity
protein tyrosine kinase activity
Ras guanyl-nucleotide exchange factor activity
cytokine activity
ErbB-2 class receptor binding
integrin binding
growth factor activity
transmembrane receptor protein tyrosine kinase activator activity
receptor tyrosine kinase binding
ErbB-3 class receptor binding
chemorepellent activity
phosphatidylinositol-4,5-bisphosphate 3-kinase activity
growth factor
MAPK cascade
activation of MAPK activity
cell morphogenesis
startle response
cardiac conduction system development
ventricular trabecula myocardium morphogenesis
cell communication
activation of transmembrane receptor protein tyrosine kinase activity
nervous system development
synapse assembly
peripheral nervous system development
locomotory behavior
regulation of blood pressure
positive regulation of cell proliferation
embryo development
neural crest cell development
regulation of phosphatidylinositol 3-kinase signaling
positive regulation of phosphatidylinositol 3-kinase signaling
glucose transport
peptidyl-tyrosine phosphorylation
glial cell fate commitment
chemorepulsion involved in interneuron migration from the subpallium to the cortex
mammary gland development
positive regulation of myelination
activation of protein kinase B activity
intracellular signal transduction
ERBB signaling pathway
ERBB2 signaling pathway
wound healing
negative regulation of protein catabolic process
myelination
regulation of protein homodimerization activity
regulation of protein heterodimerization activity
positive regulation of GTPase activity
neurotransmitter receptor metabolic process
positive regulation of axon extension
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of Ras protein signal transduction
phosphatidylinositol phosphorylation
phosphatidylinositol-mediated signaling
neuron fate commitment
oligodendrocyte differentiation
positive regulation of peptidyl-tyrosine phosphorylation
negative regulation of secretion
positive regulation of striated muscle cell differentiation
positive regulation of protein kinase B signaling
cardiac muscle cell differentiation
cardiac muscle cell myoblast differentiation
endocardial cell differentiation
positive regulation of dendritic spine development
positive regulation of calcineurin-NFAT signaling cascade
positive regulation of protein targeting to mitochondrion
positive regulation of protein localization to cell surface
regulation of cell motility
positive regulation of cardiac muscle cell differentiation
negative regulation of neuron migration
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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