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Invitrogen
NSD2 Monoclonal Antibody (CL1063)
FIGURE: 1 / 1
NSD2 Antibody (MA5-24621) in ICC/IF
The Kaohsiung journal of medical sciences 2022 -
3 FIGURE ATF2 silencing reduces expression of WHSC1 in HCC cells. (A) data in the hTFtarget database suggests WHSC1 as a downstream target of ATF2; (B) conservative binding site of ATF2; (C) putative binding site between WHSC1 and ATF2; (D,E) mRNA (D) and protein (E) expression of WHSC1in clinically collected HCC tumor tissues and the paired normal tissues ( n = 50) examined by RT-qPCR and IHC staining (pai... View More
Product Details
MA5-24621
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Not Applicable
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
CL1063
Immunogen
Recombinant protein corresponding to Human NSD2
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2637236
Product Specific Information
Immunogen sequence: SANGKTPSCE VNRECSVFLS KAQLSSSLQE GVMQKFNGHD ALPFIPADKL KDLTSRVFNG EPGAHDAKLR FESQEMKGIG TPPNTTPIKN GSPEIKLKIT KTYMNGKPLF ESSICGD
Highest antigen sequence identity to the following orthologs: Mouse - 91%, Rat - 91%.
Binds to an epitope located within the peptide sequence ALPFIPADKL as determined by overlapping synthetic peptides.
Target Information
This gene encodes a protein that contains four domains present in other developmental proteins: a PWWP domain, an HMG box, a SET domain, and a PHD-type zinc finger. It is expressed ubiquitously in early development. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene maps to the 165 kb WHS critical region and has also been involved in the chromosomal translocation t(4;14)(p16.3;q32.3) in multiple myelomas. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. Some transcript variants are nonsense-mediated mRNA (NMD) decay candidates, hence not represented as reference sequences.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Histone-lysine N-methyltransferase NSD2; IL5 promoter REII region-binding protein; MMSET; multiple myeloma SET domain containing protein type III; Multiple myeloma SET domain-containing protein; nuclear receptor binding SET domain protein 2; Nuclear SET domain-containing protein 2; probable histone-lysine N-methyltransferase NSD2; Protein trithorax-5; trithorax/ash1-related protein 5; Wolf-Hirschhorn syndrome candidate 1 protein
Gene Aliases: KIAA1090; MMSET; NSD2; REIIBP; TRX5; WHS; WHSC1
UniProt ID: (Human) O96028
Entrez Gene ID: (Human) 7468
negative regulation of transcription from RNA polymerase II promoter
membranous septum morphogenesis
atrial septum primum morphogenesis
atrial septum secundum morphogenesis
double-strand break repair via nonhomologous end joining
transcription, DNA-templated
anatomical structure morphogenesis
histone H3-K36 methylation
chromatin modification
histone H4-K20 methylation
positive regulation of isotype switching to IgA isotypes
bone development
regulation of establishment of protein localization
regulation of double-strand break repair via nonhomologous end joining
Performance Guarantee
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