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Invitrogen
NSDHL Polyclonal Antibody
Advanced Verification
This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.
Product Details
PA5-51417
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human NSDHL. Recombinant protein control fragment (Product #RP-91901).
Conjugate
Form
Liquid
Concentration
0.20 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2644808
Product Specific Information
Immunogen sequence: LPYAMKPIDY YTETKILQER AVLGANDPEK NFLTTAIRPH GIFGPRDPQL VPILIEAARN GKMKFVIGNG KNLVDFTFVE NVVHGHILAA EQLSRDSTLG GKAFHITNDE PIPFWTFLSR I
Highest antigen sequence identity to the following orthologs: Mouse - 91%, Rat - 92%.
Target Information
The protein encoded by this gene is localized in the endoplasmic reticulum and is involved in cholesterol biosynthesis. Mutations in this gene are associated with CHILD syndrome, which is a X-linked dominant disorder of lipid metabolism with disturbed cholesterol biosynthesis, and typically lethal in males. Alternatively spliced transcript variants with differing 5' UTR have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: bare patches; NAD(P)-dependent steroid dehydrogenase-like protein; Protein H105e3; short chain dehydrogenase/reductase family 31E, member 1; Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating; striated
Gene Aliases: AI747449; Bpa; H105E3; NSDHL; SDR31E1; Str; XAP104
UniProt ID: (Human) Q15738, (Mouse) Q9R1J0, (Rat) Q5PPL3
Entrez Gene ID: (Human) 50814, (Mouse) 18194, (Rat) 309262
C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity
3-beta-hydroxy-delta5-steroid dehydrogenase activity
sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity
oxidoreductase activity
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
molecular_function
dehydratase
hair follicle development
cholesterol biosynthetic process
smoothened signaling pathway
oxidation-reduction process
labyrinthine layer blood vessel development
lipid metabolic process
steroid biosynthetic process
steroid metabolic process
cholesterol metabolic process
sterol biosynthetic process
biological_process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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