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Product Details
PA5-51213
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Full length fusion protein of human NUDT4
Conjugate
Form
Liquid
Concentration
0.8 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 40% glycerol
Contains
0.05% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2636661
Product Specific Information
The antibody detects endogenous levels of total NUDT4 protein.
Target Information
Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), PP-InsP4 and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphate Ap6A, but not Ap5A. The major reaction products are ADP and p4a from Ap6A. Also able to hydrolyze 5-phosphoribose 1-diphosphate. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 2; Diphosphoinositol polyphosphate phosphohydrolase 2; Diphosphoinositol polyphosphate phosphohydrolase NUDT4B; diphosphoinositol polyphosphate phosphohydrolase type 2; DIPP-2; DIPP-2B; Nucleoside diphosphate-linked moiety X motif 4; Nucleoside diphosphate-linked moiety X motif 4B; nudix (nucleoside diphosphate linked moiety X)-type motif 4; Nudix hydrolase 4B; Nudix motif 4; Nudix motif 4B
Gene Aliases: DIPP2; DIPP2alpha; DIPP2beta; HDCMB47P; KIAA0487; NUDT4; NUDT4B
UniProt ID: (Human) A0A024RBG1
Entrez Gene ID: (Human) 11163
protein binding
diphosphoinositol-polyphosphate diphosphatase activity
snoRNA binding
metal ion binding
m7G(5')pppN diphosphatase activity
inositol diphosphate tetrakisphosphate diphosphatase activity
inositol bisdiphosphate tetrakisphosphate diphosphatase activity
inositol diphosphate pentakisphosphate diphosphatase activity
inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity
inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity
inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity
inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity
inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity
inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity
phosphatase
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