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Alomone Labs, LTD
Nectin-2/PVRL2 (extracellular) Polyclonal Antibody
FIGURE: 1 / 3
Nectin-2/PVRL2 (extracellular) Antibody (ANR-052-200UL) in IHC (F)
Expression of Nectin-2 in rat hippocampus - Immunohistochemical staining of perfusion-fixed frozen rat brain sections using Anti-Nectin-2/PVRL2 (extracellular) Antibody (#ANR-052), (1:600), followed by goat- Anti-rabbit-AleaxaFluor-488. Nectin-2 staining (green) appears in in apical dendrites of CA1 pyramidal neurons (vertical arrows) and in astrocytes (horizontal arrows). Cell nuclei are stained with DAPI ... View More
Product Details
ANR-052-200UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
(C)RVIAQPENHAEAQE, corresponding to amino acid residues 148-161 of mouse Nectin-2, Extracellular, N-terminus
Conjugate
Form
Lyophilized
Concentration
0.8 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 1% BSA
Contains
0.05% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C, protected from the light, for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 X g 5 min).
Target Information
This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD112; Herpes virus entry mediator B; Herpesvirus entry mediator B; herpesvirus entry protein B; hveB; mHveB; Murine herpes virus entry protein B; murine herpesvirus entry protein B; Nectin cell adhesion molecule 2; Nectin-2; Poliovirus receptor homolog; poliovirus receptor related 2; poliovirus receptor-like 2; poliovirus receptor-related 2 (herpesvirus entry mediator B); Poliovirus receptor-related protein 2; poliovirus sensitivity
Gene Aliases: AI325026; AI987993; CD112; HVEB; MPH; nectin-2; NECTIN2; PRR2; Pvr; PVRL2; PVRR2; Pvs
UniProt ID: (Human) Q92692, (Mouse) P32507
Entrez Gene ID: (Human) 5819, (Rat) 308417, (Mouse) 19294
acrosome assembly
positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
positive regulation of immunoglobulin mediated immune response
cytoskeleton organization
homophilic cell adhesion via plasma membrane adhesion molecules
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
signal transduction
spermatid development
spermatid nucleus differentiation
cell recognition
fertilization
fusion of virus membrane with host plasma membrane
sperm mitochondrion organization
cell part morphogenesis
positive regulation of mast cell activation
adherens junction organization
susceptibility to natural killer cell mediated cytotoxicity
adhesion of symbiont to host
cilium organization
positive regulation of natural killer cell mediated cytotoxicity
regulation of viral entry into host cell
coreceptor-mediated virion attachment to host cell
regulation of immune response
establishment of mitochondrion localization
susceptibility to T cell mediated cytotoxicity
biological_process
cell adhesion
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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