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Invitrogen
Nesprin 1 Recombinant Rabbit Monoclonal Antibody (1D4D9)
Product Details
MA5-42738
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
1D4D9
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 8200-8400 of human Nesprin 1 (Q8NF91).
Conjugate
Form
Liquid
Concentration
0.6 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 0.05% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2911879
Product Specific Information
Immunogen sequence: FGRVERYHKK LIRLPLPDDE HDLSDRELEL EDSAALSDLH WHDRSADSLL SPQPSSNLSL SLAQPLRSER SGRDTPASVD SIPLEWDHDY DLSRDLESAM SRALPSEDEE GQDDKDFYLR GAVGLSGDHS ALESQIRQLG KALDDSRFQI QQTENIIRSK TPTGPELDTS YKGYMKLLGE CSSSIDSVKR LEHKLKEEEE S
Target Information
There are two genes encoding members of a new family of type II integral membrane proteins. Both are ubiquitously expressed, and tissue-specific alternative mRNA initiation and splicing generate at least two major isoforms of each protein, with the smaller isoforms being truncated at the N-terminus. These proteins are called nesprin-l and -2 for nuclear _envelope _spectrin repeat, as they are characterized by the presence of multiple, clustered spectrin repeats, bipartite nuclear localization sequences and a conserved C-terminal, single transmembrane domain. Transient transfection of EGFP-fusion expression constructs demonstrated their localization to the nuclear membrane with a novel C-terminal, TM-domain-containing sequence essential for perinuclear localization. Nesprin-l is developmentally regulated in both smooth and skeletal muscle and is relocalized from the nuclear envelope to the nucleus and cytoplasm during C2Cl2 myoblast differentiation. Nesprins may function as 'dystrophins of the nucleus' to maintain nuclear organization and structura integrity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CPG2 full length; DKFZp781J13156; Enaptin; enaptin165; FLJ30878; FLJ41140; KASH domain-containing protein 1; KASH1; Myne-1; Myocyte nuclear envelope protein 1; nesprin 1; Nesprin-1; Nuclear envelope spectrin repeat protein 1; RP1-130E4.2; spectrin repeat containing, nuclear envelope 1; synaptic nuclear envelope 1; Synaptic nuclear envelope protein 1; synaptic nuclei expressed gene 1; SYNE 1; Syne-1; syne-1 fragment
Gene Aliases: 8B; A330049M09Rik; ARCA1; BE692247; C130039F11Rik; C6orf98; CPG2; dJ45H2.2; EDMD4; KIAA0796; KIAA1262; KIAA1756; mKIAA1756; MYNE1; Nesp1; SCAR8; SYNE1
UniProt ID: (Human) Q8NF91, (Mouse) Q6ZWR6
Entrez Gene ID: (Human) 23345, (Mouse) 64009
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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