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Product Details
PA5-115644
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human NEUROG2(Accession Q9H2A3), corresponding to amino acid residues A189-S239.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2900279
Product Specific Information
Antibody detects endogenous levels of total NEUROG2.
Target Information
Neurogenin-2 is a member of the neurogenin subfamily of basic helix-loop-helix (bHLH) transcription factor genes that play an important role in neurogenesis from migratory neural crest cells. In the course of mouse neurogenesis, Ngn2 and Ngn1 are expressed in distinct progenitor populations residing in the central and peripheral nervous systems. Mutation analyses demonstrate that Ngn1 is required for the determination of neuronal precursors for proximal cranial sensory ganglia and that Ngn2 is necessary for the determination of precursors for epibranchial placode-derived sensory neurons.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: atonal homolog 4; bHLHa8; Class A basic helix-loop-helix protein 8; Helix-loop-helix protein mATH-4A; mATH4A; Neurogenin-2; neurogenin2; NGN-2; Protein atonal homolog 4
Gene Aliases: Ath4a; ATOH4; BHLHA8; Math4A; NEUROG2; ngn-2; NGN2
UniProt ID: (Human) Q9H2A3, (Mouse) P70447
Entrez Gene ID: (Human) 63973, (Mouse) 11924
transcription, DNA-templated
neuron differentiation
positive regulation of sequence-specific DNA binding transcription factor activity
neuron migration
regulation of transcription, DNA-templated
multicellular organism development
nervous system development
axon guidance
central nervous system neuron development
neurogenesis
cell differentiation
forebrain development
cell fate commitment
positive regulation of neuron differentiation
positive regulation of transcription from RNA polymerase II promoter
cell maturation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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