Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
The antigen is homologous with Neuroligin 2.
Specificity of this antibody: Neuroligin 1, 2.
Neuroligins are a family of plasma membrane proteins that possess an N-terminal hydrophobic domain, a large esterase homology domain, a single transmembrane region, a short cytoplasmic domain, and an EF-hand binding domain (1,2). Members of the neuroligin family include Neuroligin 1, Neuroligin 2 and Neuroligin 3. Neuroligins are expressed in excitatory neuronal synaptic clefts. Neuroligins play a role in the formation and remodeling of CNS synapses by binding to b-neurexins, a family of neuronal cell surface proteins. Neuroexin 1b binds to the EF-hand domain of Neuroligin 1 and requires calcium ion. Neuroligins also bind to PSD-95, which may recruit ion channels and neurotransmitter receptors to the synapses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Neuroligin I; Neuroligin-1; Neuroligin-2; ortholog of human and rat neuroligin 2 NLGN2
Gene Aliases: 6330415N05Rik; BB179718; KIAA1070; KIAA1366; mKIAA1070; NL1; NL2; Nlg1; NLGN1; NLGN2
UniProt ID: (Human) Q8N2Q7, (Human) Q8NFZ4, (Mouse) Q99K10, (Rat) Q62765, (Rat) Q62888, (Mouse) Q69ZK9
Entrez Gene ID: (Human) 22871, (Human) 57555, (Mouse) 192167, (Rat) 116647, (Rat) 117096, (Mouse) 216856
Molecular Function:
cell adhesion molecule
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