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Neuropilin 1 Monoclonal Antibody (2H3F6)

Neuropilin 1 Antibody in Immunocytochemistry (ICC/IF)

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Neuropilin 1 Antibody (60067-1-IG) in ICC/IF

Confocal immunofluorescent analysis of human embronic stem cells with 60067-1-IG at dilution of 1:100. DAPI was used to stain the cell nuclei (blue) at a concentration of 1 µg/mL. This photo is the merge of PE and DAPI. (40X).

Neuropilin 1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Neuropilin 1 Antibody in Western Blot (WB)

Neuropilin 1 Antibody in Flow Cytometry (Flow)

Product Image Gallery

Product Details

60067-1-IG

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:4,000

View 8 publications 8 publications

Immunohistochemistry (IHC)

View 6 publications 6 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

1:50-1:500

View 8 publications 8 publications

Flow Cytometry (Flow)

Assay-dependent

Immunoprecipitation (IP)

View 2 publications 2 publications

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Pig

Published species

Human, Mouse

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

2H3F6

Immunogen

Neuropilin 1 Fusion Protein Ag0931 (1-300 aa encoded by BC007737)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Caprylic acid precipitation

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.1% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MERGLPLLC AVLALVLAPA GAFRNDKCGD TIKIESPGYL TSPGYPHSYH PSEKCEWLIQ APDPYQRIMI NFNPHFDLED RDCKYDYVEV FDGENENGHF RGKFCGKIAP PPVVSSGPFL FIKFVSDYET HGAGFSIRYE IFKRGPECSQ NYTTPSGVIK SPGFPEKYPN SLECTYIVFA PKMSEIILEF ESFDLEPDSN PPGGMFCRYD RLEIWDGFPD VGPHIGRYCG QKTPGRIRSS SGILSMVFYT DSAIAKEGFS ANYSVLQSSV SEDFKCMEAL GMESGEIHSD QITASSQYST N (1-300 aa encoded by BC007737)

Target Information

Neuropilin 1 is a 923 amino acid containing membrane bound coreceptor to a tyrosine kinase receptor belonging to the neuropilin family with two CUB domains, two F5/8 type C domains and a MAM domain. Neuropilin 1 forms a heterodimer with NRP2 (Neuropilin 2) and is known to bind to plexin (PLXNB1) to form semaphorin receptors. Expressed mostly in the nervous system this receptor is implicated in a wide range of functions including in the development of the cardiovascular system, angiogenesis, repulsive axon guidance, formation of certain neuronal circuits, cell survival, control of neuronal migration and organogenesis outside the nervous system. This semaphorin receptor functions as receptors for both the semaphorins and vascular endothelial growth factor and is also a regulator of VEGF-induced angiogenesis. Neuropilin 1 may be involved in aggressive advanced prostate carcinoma and in the progression of breast cancer.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Comprehensive analysis of cuproptosis-related immune biomarker signature to enhance prognostic accuracy in gastric cancer.

Aging

Li J,Yu T,Sun J,Zeng Z,Liu Z,Ma M,Zheng Z,He Y,Kang W

Fri Apr 07 00:00:00 EDT 2023

Potassium Dehydroandrograpolide Succinate Targets NRP1 Mediated VEGFR2/VE-Cadherin Signaling Pathway to Promote Endothelial Barrier Repair.

International journal of molecular sciences

Wang Z,Wu X,Li J,Guo Q,Jin Z,Li H,Liang B,Hu W,Xu H,Shi L,Yang L,Wang Y

Sat Feb 04 00:00:00 EST 2023

Potassium Dehydroandrograpolide Succinate Targets NRP1 Mediated VEGFR2/VE-Cadherin Signaling Pathway to Promote Endothelial Barrier Repair.

International journal of molecular sciences

Wang Z,Wu X,Li J,Guo Q,Jin Z,Li H,Liang B,Hu W,Xu H,Shi L,Yang L,Wang Y

Sat Feb 04 00:00:00 EST 2023

Potassium Dehydroandrograpolide Succinate Targets NRP1 Mediated VEGFR2/VE-Cadherin Signaling Pathway to Promote Endothelial Barrier Repair.

International journal of molecular sciences

Wang Z,Wu X,Li J,Guo Q,Jin Z,Li H,Liang B,Hu W,Xu H,Shi L,Yang L,Wang Y

Sat Feb 04 00:00:00 EST 2023

Potassium Dehydroandrograpolide Succinate Targets NRP1 Mediated VEGFR2/VE-Cadherin Signaling Pathway to Promote Endothelial Barrier Repair.

International journal of molecular sciences

Wang Z,Wu X,Li J,Guo Q,Jin Z,Li H,Liang B,Hu W,Xu H,Shi L,Yang L,Wang Y

Sat Feb 04 00:00:00 EST 2023

Potassium Dehydroandrograpolide Succinate Targets NRP1 Mediated VEGFR2/VE-Cadherin Signaling Pathway to Promote Endothelial Barrier Repair.

International journal of molecular sciences

Wang Z,Wu X,Li J,Guo Q,Jin Z,Li H,Liang B,Hu W,Xu H,Shi L,Yang L,Wang Y

Sat Feb 04 00:00:00 EST 2023

Potassium Dehydroandrograpolide Succinate Targets NRP1 Mediated VEGFR2/VE-Cadherin Signaling Pathway to Promote Endothelial Barrier Repair.

International journal of molecular sciences

Wang Z,Wu X,Li J,Guo Q,Jin Z,Li H,Liang B,Hu W,Xu H,Shi L,Yang L,Wang Y

Sat Feb 04 00:00:00 EST 2023

Potassium Dehydroandrograpolide Succinate Targets NRP1 Mediated VEGFR2/VE-Cadherin Signaling Pathway to Promote Endothelial Barrier Repair.

International journal of molecular sciences

Wang Z,Wu X,Li J,Guo Q,Jin Z,Li H,Liang B,Hu W,Xu H,Shi L,Yang L,Wang Y

Sat Feb 04 00:00:00 EST 2023

Potassium Dehydroandrograpolide Succinate Targets NRP1 Mediated VEGFR2/VE-Cadherin Signaling Pathway to Promote Endothelial Barrier Repair.

International journal of molecular sciences

Wang Z,Wu X,Li J,Guo Q,Jin Z,Li H,Liang B,Hu W,Xu H,Shi L,Yang L,Wang Y

Sat Feb 04 00:00:00 EST 2023

NRP1 contributes to stemness and potentiates radioresistance via WTAP-mediated m6A methylation of Bcl-2 mRNA in breast cancer.

Apoptosis : an international journal on programmed cell death

Wang Y,Zhang L,Sun XL,Lu YC,Chen S,Pei DS,Zhang LS

Wed Feb 01 00:00:00 EST 2023

NRP1 contributes to stemness and potentiates radioresistance via WTAP-mediated m6A methylation of Bcl-2 mRNA in breast cancer.

Apoptosis : an international journal on programmed cell death

Wang Y,Zhang L,Sun XL,Lu YC,Chen S,Pei DS,Zhang LS

Wed Feb 01 00:00:00 EST 2023

NRP1 contributes to stemness and potentiates radioresistance via WTAP-mediated m6A methylation of Bcl-2 mRNA in breast cancer.

Apoptosis : an international journal on programmed cell death

Wang Y,Zhang L,Sun XL,Lu YC,Chen S,Pei DS,Zhang LS

Wed Feb 01 00:00:00 EST 2023

NRP1 contributes to stemness and potentiates radioresistance via WTAP-mediated m6A methylation of Bcl-2 mRNA in breast cancer.

Apoptosis : an international journal on programmed cell death

Wang Y,Zhang L,Sun XL,Lu YC,Chen S,Pei DS,Zhang LS

Wed Feb 01 00:00:00 EST 2023

SARS-CoV2 entry factors are expressed in primary human glioblastoma and recapitulated in cerebral organoid models.

Journal of neuro-oncology

Suarez-Meade P,Watanabe F,Ruiz-Garcia H,Rafferty SB,Moniz-Garcia D,Schiapparelli PV,Jentoft ME,Imitola J,Quinones-Hinojosa A

Sun Jan 01 00:00:00 EST 2023

SARS-CoV2 entry factors are expressed in primary human glioblastoma and recapitulated in cerebral organoid models.

Journal of neuro-oncology

Suarez-Meade P,Watanabe F,Ruiz-Garcia H,Rafferty SB,Moniz-Garcia D,Schiapparelli PV,Jentoft ME,Imitola J,Quinones-Hinojosa A

Sun Jan 01 00:00:00 EST 2023

The FDA-approved drug Auranofin has a dual inhibitory effect on SARS-CoV-2 entry and NF-κB signaling.

iScience

Laplantine E,Chable-Bessia C,Oudin A,Swain J,Soria A,Merida P,Gourdelier M,Mestiri S,Besseghe I,Bremaud E,Neyret A,Lyonnais S,Favard C,Benaroch P,Hubert M,Schwartz O,Guerin M,Danckaert A,Del Nery E,Muriaux D,Weil R

Fri Oct 21 00:00:00 EDT 2022

The Expression Levels of SARS-CoV-2 Infection-Mediating Molecules Promoted by Interferon-γ and Tumor Necrosis Factor-α Are Downregulated by Hydrogen Sulfide.

International journal of molecular sciences

Zhao X,Cao Y,Zhao E,Li T,Cong T,Gao Y,Zhang J

Mon Nov 07 00:00:00 EST 2022

The Expression Levels of SARS-CoV-2 Infection-Mediating Molecules Promoted by Interferon-γ and Tumor Necrosis Factor-α Are Downregulated by Hydrogen Sulfide.

International journal of molecular sciences

Zhao X,Cao Y,Zhao E,Li T,Cong T,Gao Y,Zhang J

Mon Nov 07 00:00:00 EST 2022

Expression of axon guidance ligands and their receptors in the cornea and trigeminal ganglia and their recovery after corneal epithelium injury.

Experimental eye research

Guaiquil VH,Xiao C,Lara D,Dimailig G,Zhou Q

Wed Jun 01 00:00:00 EDT 2022

Perivascular Neuropilin-1 expression is an independent marker of improved survival in renal cell carcinoma.

The Journal of pathology

Morin E,Lindskog C,Johansson M,Egevad L,Sandström P,Harmenberg U,Claesson-Welsh L,Sjöberg E

Wed Apr 01 00:00:00 EDT 2020

Cdc42 subcellular relocation in response to VEGF/NRP1 engagement is associated with the poor prognosis of colorectal cancer.

Cell death & disease

Ma LL,Guo LL,Luo Y,Liu GL,Lei Y,Jing FY,Zhang YL,Tong GH,Jing ZL,Shen L,Tang MS,Ding YQ,Deng YJ

Thu Mar 05 00:00:00 EST 2020

CMTM6 promotes cell proliferation and invasion in oral squamous cell carcinoma by interacting with NRP1.

American journal of cancer research

Zheng Y,Wang C,Song A,Jiang F,Zhou J,Li G,Zhang W,Ye J,Ding X,Zhang W,Du Y,Zhang H,Wu H,Song X,Wu Y

Mon Sep 28 00:00:00 EDT 2020

Receptor-specific interactome as a hub for rapid cue-induced selective translation in axons.

eLife

Koppers M,Cagnetta R,Shigeoka T,Wunderlich LC,Vallejo-Ramirez P,Qiaojin Lin J,Zhao S,Jakobs MA,Dwivedy A,Minett MS,Bellon A,Kaminski CF,Harris WA,Flanagan JG,Holt CE

Wed Nov 20 00:00:00 EST 2019

RNA binding protein PUM2 promotes the stemness of breast cancer cells via competitively binding to neuropilin-1 (NRP-1) mRNA with miR-376a.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Zhang L,Chen Y,Li C,Liu J,Ren H,Li L,Zheng X,Wang H,Han Z

Sat Jun 01 00:00:00 EDT 2019

NRP1 haploinsufficiency predisposes to the development of Tetralogy of Fallot.

American journal of medical genetics. Part A

Duran I,Tenney J,Warren CM,Sarukhanov A,Csukasi F,Skalansky M,Iruela-Arispe ML,Krakow D

Thu Mar 01 00:00:00 EST 2018

NRP1 haploinsufficiency predisposes to the development of Tetralogy of Fallot.

American journal of medical genetics. Part A

Duran I,Tenney J,Warren CM,Sarukhanov A,Csukasi F,Skalansky M,Iruela-Arispe ML,Krakow D

Thu Mar 01 00:00:00 EST 2018

Dual Receptor Targeting Cell Penetrating Peptide Modified Liposome for Glioma and Breast Cancer Postoperative Recurrence Therapy.

Pharmaceutical research

Qiu Y,Yu Q,Liu Y,Tang J,Wang X,Lu Z,Xu Z,He Q

Thu Apr 26 00:00:00 EDT 2018

Semaphorin-3a, neuropilin-1 and plexin-A1 in prosthetic-particle induced bone loss.

Acta biomaterialia

Saad S,Dharmapatni AASSK,Crotti TN,Cantley MD,Algate K,Findlay DM,Atkins GJ,Haynes DR

Fri Jan 01 00:00:00 EST 2016

Semaphorin-3a, neuropilin-1 and plexin-A1 in prosthetic-particle induced bone loss.

Acta biomaterialia

Saad S,Dharmapatni AASSK,Crotti TN,Cantley MD,Algate K,Findlay DM,Atkins GJ,Haynes DR

Fri Jan 01 00:00:00 EST 2016

Semaphorin-3a, neuropilin-1 and plexin-A1 in prosthetic-particle induced bone loss.

Acta biomaterialia

Saad S,Dharmapatni AASSK,Crotti TN,Cantley MD,Algate K,Findlay DM,Atkins GJ,Haynes DR

Fri Jan 01 00:00:00 EST 2016

MiR-338 suppresses the growth and metastasis of OSCC cells by targeting NRP1.

Molecular and cellular biochemistry

Liu C,Wang Z,Wang Y,Gu W

Thu Jan 01 00:00:00 EST 2015

MiR-338 suppresses the growth and metastasis of OSCC cells by targeting NRP1.

Molecular and cellular biochemistry

Liu C,Wang Z,Wang Y,Gu W

Thu Jan 01 00:00:00 EST 2015

Bioinformatics

Protein Aliases: CD304; Neuropilin; Neuropilin-1; Neuropilin1; NRP 1; sNRP 1; sNRP1; soluble NRP 1; soluble NRP1; transmembrane receptor; Vascular endothelial cell growth factor 165 receptor

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Gene Aliases: BDCA4; CD304; NP1; NRP; NRP1; VEGF165R

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UniProt ID: (Human) O14786

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Entrez Gene ID: (Human) 8829, (Pig) 100286859

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Function(s)

vascular endothelial growth factor-activated receptor activity protein binding heparin binding coreceptor activity semaphorin receptor activity growth factor binding cytokine binding vascular endothelial growth factor binding metal ion binding oxidoreductase

Process(es)

angiogenesis patterning of blood vessels neuron migration positive regulation of endothelial cell proliferation sprouting angiogenesis cell migration involved in sprouting angiogenesis signal transduction cell-cell signaling axon guidance axonal fasciculation response to wounding organ morphogenesis positive regulation of endothelial cell migration positive regulation of smooth muscle cell migration dendrite development facial nerve structural organization trigeminal nerve structural organization vestibulocochlear nerve structural organization nerve development branchiomotor neuron axon guidance gonadotrophin-releasing hormone neuronal migration to the hypothalamus retinal ganglion cell axon guidance cellular response to hepatocyte growth factor stimulus endothelial cell chemotaxis cellular response to vascular endothelial growth factor stimulus ventral trunk neural crest cell migration VEGF-activated neuropilin signaling pathway otic placode formation negative regulation of neuron apoptotic process platelet-derived growth factor receptor signaling pathway vascular endothelial growth factor receptor signaling pathway hepatocyte growth factor receptor signaling pathway positive regulation of axon extension involved in axon guidance negative regulation of axon extension involved in axon guidance artery morphogenesis axon extension involved in axon guidance positive regulation of peptidyl-tyrosine phosphorylation positive chemotaxis positive regulation of cytokine activity axonogenesis involved in innervation regulation of vesicle-mediated transport dichotomous subdivision of terminal units involved in salivary gland branching angiogenesis involved in coronary vascular morphogenesis coronary artery morphogenesis retina vasculature morphogenesis in camera-type eye renal artery morphogenesis sympathetic ganglion development trigeminal ganglion development positive regulation of ERK1 and ERK2 cascade semaphorin-plexin signaling pathway commissural neuron axon guidance regulation of retinal ganglion cell axon guidance endothelial tip cell fate specification sensory neuron axon guidance sympathetic neuron projection extension sympathetic neuron projection guidance neural crest cell migration involved in autonomic nervous system development toxin transport semaphorin-plexin signaling pathway involved in neuron projection guidance semaphorin-plexin signaling pathway involved in axon guidance positive regulation of retinal ganglion cell axon guidance VEGF-activated neuropilin signaling pathway involved in axon guidance protein localization to early endosome facioacoustic ganglion development dorsal root ganglion morphogenesis negative regulation of extrinsic apoptotic signaling pathway

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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Neuropilin 1 Monoclonal Antibody (2H3F6)

Neuropilin 1 Antibody (60067-1-IG) in ICC/IF

Product Details

60067-1-IG

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Immunoprecipitation (IP)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Clone

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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