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Product Details
PA5-102693
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human NKX2-1(Accession P43699), corresponding to amino acid residues M1-P49.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2852088
Product Specific Information
Antibody detects endogenous levels of total TTF1.
Target Information
This gene encodes a protein initially identified as a thyroid-specific transcription factor. The encoded protein binds to thyroglobulin promoter and regulates the expression of thyroid-specific genes but has also been shown to regulate the expression of genes involved in morphogenesis. Mutations and deletions in this gene are associated with benign hereditary chorea, choreoathetosis, congenital hypothyroidism, and neonatal respiratory distress, and may be associated with thyroid cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Homeobox protein NK-2 homolog A; Homeobox protein Nkx-2.1; NK-2 homolog A; T/EBP; Thyroid nuclear factor 1; Thyroid transcription factor 1; thyroid transcription factor 1 TTF-1 NK-2; Thyroid-specific enhancer-binding protein; tinman; TTF-1; TTF1
Gene Aliases: AV026640; BCH; BHC; NK-2; Nkx-2.1; NKX2-1; NKX2.1; NKX2A; NMTC1; T/EBP; TEBP; TITF1; TTF-1; TTF1
UniProt ID: (Human) P43699, (Mouse) P50220
Entrez Gene ID: (Human) 7080, (Mouse) 21869, (Rat) 25628
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II regulatory region DNA binding
core promoter binding
intronic transcription regulatory region sequence-specific DNA binding
DNA binding
transcription factor activity, sequence-specific DNA binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
protein binding
enzyme binding
transcription regulatory region DNA binding
intronic transcription regulatory region DNA binding
transcription factor binding
sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
homeodomain transcription factor
negative regulation of transcription from RNA polymerase II promoter
neuron migration
regulation of blood volume by renin-angiotensin
transcription, DNA-templated
phospholipid metabolic process
axon guidance
brain development
endoderm development
locomotory behavior
feeding behavior
response to hormone
positive regulation of gene expression
negative regulation of epithelial to mesenchymal transition
globus pallidus development
hippocampus development
cerebral cortex cell migration
forebrain dorsal/ventral pattern formation
forebrain neuron fate commitment
cerebral cortex GABAergic interneuron differentiation
pituitary gland development
lung development
negative regulation of cell migration
negative regulation of transforming growth factor beta receptor signaling pathway
thyroid gland development
forebrain development
developmental induction
response to lipopolysaccharide
Leydig cell differentiation
hyperosmotic salinity response
positive regulation of circadian rhythm
response to ethanol
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
development of primary female sexual characteristics
rhythmic process
anatomical structure formation involved in morphogenesis
oligodendrocyte differentiation
lung saccule development
epithelial tube branching involved in lung morphogenesis
Clara cell differentiation
Type II pneumocyte differentiation
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
pattern specification process
organ morphogenesis
telencephalon development
forebrain neuron differentiation
cerebral cortex neuron differentiation
telencephalon cell migration
menarche
neuron fate commitment
circadian rhythm
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