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Product Details
PA1-4519
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to an internal sequence (CTERHGLKEPKRVEE) of human Nurr1 protein.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2267349
Product Specific Information
PA1-4519 detects Nurr1 in human, rat, and mouse samples.
PA1-4519 has been successfully used in Western blot and Immunohistochemistry procedures. This antibody is specific for the ~70 kDa protein representing Nurr1.
PA1-4519 immunogen is a synthetic peptide corresponding to an internal sequence (CTERHGLKEPKRVEE) of human Nurr1 protein.
Target Information
The Nuclear receptor related 1 protein (Nurr1) also known as NR4A2 (nuclear receptor subfamily 4, group A, member 2) is a protein that in humans is encoded by the NR4A2 gene. NURR1 is a member of the nuclear receptor family of intracellular transcription factors.Nurr1 plays a key role in the maintenance of the dopaminergic system of the brain. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson's disease, schizophrenia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Four transcript variants encoding four distinct isoforms have been identified for this gene. Additional alternate splice variants may exist, but their full-length nature has not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: HZF3; Immediate-early response protein NOT; intermediate-early receptor protein; NGFI-B beta; NGFI-B/nur77 beta-type transcription factor homolog; Nuclear orphan receptor HZF-3; nuclear receptor related 1; Nuclear receptor subfamily 4 group A member 2; nuclear receptor subfamily 4 group A member 2 variant TINUR; nuclear receptor subfamily 4 group A member 2 variant NURR1a; nuclear receptor subfamily 4 group A member 2 variant NURR1b; nuclear receptor subfamily 4 group A member 2 variant NURR1c; nuclear receptor subfamily 4 group A member 2 variant NURR2c; nuclear receptor subfamily 4, group A, member 2; nur related protein 1; nur related protein-1, human homolog of; NUR-related factor 1; orphan nuclear receptor NR4A2; Orphan nuclear receptor NURR1; Regenerating liver nuclear receptor 1; RNR-1; SL-322; T-cell nuclear receptor NOT; transcriptionally inducible nuclear receptor related 1; Transcriptionally-inducible nuclear receptor
Gene Aliases: HZF-3; NOT; NR4A2; NURR1; RNR-1; RNR1; TINOR; TINUR
UniProt ID: (Human) P43354, (Mouse) Q06219, (Rat) Q07917
Entrez Gene ID: (Human) 4929, (Mouse) 18227, (Rat) 54278
RNA polymerase II core promoter sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
steroid hormone receptor activity
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
protein binding
beta-catenin binding
zinc ion binding
glucocorticoid receptor binding
protein homodimerization activity
retinoid X receptor binding
protein heterodimerization activity
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
transcription factor activity, sequence-specific DNA binding
sequence-specific DNA binding
metal ion binding
C4 zinc finger nuclear receptor
negative regulation of transcription from RNA polymerase II promoter
response to hypoxia
neuron migration
response to amphetamine
transcription, DNA-templated
transcription initiation from RNA polymerase II promoter
signal transduction
adult locomotory behavior
post-embryonic development
central nervous system projection neuron axonogenesis
habenula development
intracellular receptor signaling pathway
cellular response to extracellular stimulus
cellular response to oxidative stress
regulation of dopamine metabolic process
dopamine biosynthetic process
neuron maturation
positive regulation of catalytic activity
steroid hormone mediated signaling pathway
negative regulation of neuron apoptotic process
regulation of respiratory gaseous exchange
fat cell differentiation
positive regulation of transcription from RNA polymerase II promoter
general adaptation syndrome
canonical Wnt signaling pathway
cellular response to corticotropin-releasing hormone stimulus
dopaminergic neuron differentiation
midbrain dopaminergic neuron differentiation
negative regulation of apoptotic signaling pathway
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
nervous system development
response to inorganic substance
gene expression
regulation of gene expression
obsolete death
response to insecticide
central nervous system neuron differentiation
neuron differentiation
dopamine metabolic process
positive regulation of transcription, DNA-templated
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