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Product Details
PA5-78406
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of mouse Nurr1. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1.51 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
0.025% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2736270
Product Specific Information
Positive Control: mouse brain, rat brain
Predicted Reactivity: Human (98%), Pig (98%), Rhesus Monkey (98%), Bovine (98%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The Nuclear receptor related 1 protein (Nurr1) also known as NR4A2 (nuclear receptor subfamily 4, group A, member 2) is a protein that in humans is encoded by the NR4A2 gene. NURR1 is a member of the nuclear receptor family of intracellular transcription factors.Nurr1 plays a key role in the maintenance of the dopaminergic system of the brain. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson's disease, schizophrenia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Four transcript variants encoding four distinct isoforms have been identified for this gene. Additional alternate splice variants may exist, but their full-length nature has not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: HZF3; NGFI-B beta; Nuclear orphan receptor HZF-3; Nuclear receptor subfamily 4 group A member 2; nuclear receptor subfamily 4 group A member 2 variant TINUR; nuclear receptor subfamily 4 group A member 2 variant NURR1a; nuclear receptor subfamily 4 group A member 2 variant NURR1b; nuclear receptor subfamily 4 group A member 2 variant NURR1c; nuclear receptor subfamily 4 group A member 2 variant NURR2c; nur related protein 1; NUR-related factor 1; Orphan nuclear receptor NURR1; Regenerating liver nuclear receptor 1; RNR-1; SL-322
Gene Aliases: HZF-3; NOT; Nr4a2; Nurr1; RNR-1; Rnr1; TINOR; TINUR
UniProt ID: (Mouse) Q06219, (Rat) Q07917
Entrez Gene ID: (Mouse) 18227, (Rat) 54278
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II core promoter sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
steroid hormone receptor activity
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
protein binding
zinc ion binding
sequence-specific DNA binding
metal ion binding
protein heterodimerization activity
C4 zinc finger nuclear receptor
response to hypoxia
neuron migration
response to amphetamine
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
nervous system development
adult locomotory behavior
post-embryonic development
response to inorganic substance
gene expression
regulation of gene expression
obsolete death
response to insecticide
central nervous system projection neuron axonogenesis
central nervous system neuron differentiation
habenula development
neuron differentiation
intracellular receptor signaling pathway
cellular response to extracellular stimulus
cellular response to oxidative stress
regulation of dopamine metabolic process
dopamine biosynthetic process
dopamine metabolic process
neuron maturation
positive regulation of catalytic activity
steroid hormone mediated signaling pathway
negative regulation of neuron apoptotic process
regulation of respiratory gaseous exchange
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
general adaptation syndrome
dopaminergic neuron differentiation
Performance Guarantee
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