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Product Details
14955-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Pig
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
OAS1 Fusion Protein Ag6793 (1-351 aa encoded by BC000562)
Conjugate
Form
Liquid
Concentration
0.16 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MMDLRNTPA KSLDKFIEDY LLPDTCFRMQ INHAIDIICG FLKERCFRGS SYPVCVSKVV KGGSSGKGTT LRGRSDADLV VFLSPLTTFQ DQLNRRGEFI QEIRRQLEAC QRERAFSVKF EVQAPRWGNP RALSFVLSSL QLGEGVEFDV LPAFDALGQL TGSYKPNPQI YVKLIEECTD LQKEGEFSTC FTELQRDFLK QRPTKLKSLI RLVKHWYQNC KKKLGKLPPQ YALELLTVYA WERGSMKTHF NTAQGFRTVL ELVINYQQLC IYWTKYYDFK NPIIEKYLRR QLTKPRPVIL DPADPTGNLG GGDPKGWRQL AQEAEAWLNY PCFKNWDGSP VSSWILLVRP PA (1-351 aa encoded by BC000562)
Target Information
OAS1 is an interferon inducible protein that may play a role in mediating resistance to virus infection, control of cell growth, differentiation, and apoptosis. It binds double-stranded RNA and polymerizes ATP into PPP(A2'P5'A)N oligomers, which activate the latent RNase L that, when activated, cleaves single-stranded RNAs. This protein is associated with different subcellular fractions such as mitochondrial, nuclear, and rough/smooth microsomal fractions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: (2-5')oligo(A) synthase 1; (2-5')oligo(A) synthase 1A; (2-5')oligo(A) synthetase 1; (2-5')oligo(A) synthetase 1A; 2',5'-oligo A synthetase 1; 2',5'-oligoadenylate synthetase 1, 40/46kDa; 2'-5' oligoadenylate synthetase 1G; 2'-5'-oligoadenylate synthase 1; 2'-5'-oligoadenylate synthase 1A; 2'-5'-oligoadenylate synthetase 1; 2'-5'-oligoadenylate synthetase 1, 40/46kDa; 2'-5'-oligoisoadenylate synthetase 1; 2-5A synthase 1; 2-5A synthase 1A; 2-5A synthetase 1; 2-5A synthetase 1A; 25 oligoadenylate synthetase; E16 (2'-5') oligo A synthetase; E18/E16; IFI 4; IFI4; OAS 1; p42 OAS; p46/p42 OAS
Gene Aliases: E18/E16; IFI-4; L3; OAS1; Oas1a; Oas1g; OIAS; Oias1; OIASI
UniProt ID: (Human) P00973, (Rat) Q05961, (Mouse) P11928
Entrez Gene ID: (Human) 4938, (Rat) 192281, (Mouse) 246730
glucose metabolic process
response to virus
glucose homeostasis
negative regulation of viral genome replication
defense response to virus
interferon-gamma-mediated signaling pathway
type I interferon signaling pathway
purine nucleotide biosynthetic process
immune response
metabolic process
cellular response to interferon-alpha
innate immune response
negative regulation of viral process
protein oligomerization
regulation of ribonuclease activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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