Proteintech

OAS3 Polyclonal Antibody

OAS3 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 9

OAS3 Antibody (21915-1-AP) in ICC/IF

Immunofluorescent analysis of HeLa cells using 21915-1-AP (OAS3 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

OAS3 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Product Details

21915-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 7 publications 7 publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:20-1:200

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human

Published species

Not Applicable

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

OAS3 Fusion Protein Ag16150 (1-350 aa encoded by BC113746)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.39 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MDLYSTPAA ALDRFVARRL QPRKEFVEKA RRALGALAAA LRERGGRLGA AAPRVLKTVK GGSSGRGTAL KGGCDSELVI FLDCFKSYVD QRARRAEILS EMRASLESWW QNPVPGLRLT FPEQSVPGAL QFRLTSVDLE DWMDVSLVPA FNVLGQAGSG VKPKPQVYST LLNSGCQGGE HAACFTELRR NFVNIRPAKL KNLILLVKHW YHQVCLQGLW KETLPPVYAL ELLTIFAWEQ GCKKDAFSLA EGLRTVLGLI QQHQHLCVFW TVNYGFEDPA VGQFLQRQLK RPRPVILDPA DPTWDLGNGA AWHWDLLAQE AASCYDHPCF LRGMGDPVQS WKGPGLPRAG C (1-350 aa encoded by BC113746)

Target Information

OAS3 is an interferon inducible protein that belongs to the 2-5A synthetase family, may play a role in mediating resistance to virus infection, control of cell growth, differentiation, and apoptosis. OAS3 synthesizes preferentially dimeric 2',5'-oligoadenylate molecules. GTP can be an alternative substrate. OAS3 binds double-stranded RNA and polymerizes ATP into PPP(A2'P5'A)N oligomers, which activate the latent RNase L that, when activated, cleaves single-stranded RNAs. The protein is present at high level in placenta trophoblast.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

IFI44L as a novel epigenetic silencing tumor suppressor promotes apoptosis through JAK/STAT1 pathway during lung carcinogenesis.

Environmental pollution (Barking, Essex : 1987)

Zeng Y,Chen HQ,Zhang Z,Fan J,Li JZ,Zhou SM,Wang N,Yan SP,Cao J,Liu JY,Zhou ZY,Liu WB

Wed Feb 15 00:00:00 EST 2023

Systematic Analysis of Molecular Subtypes Based on the Expression Profile of Immune-Related Genes in Pancreatic Cancer.

Oxidative medicine and cellular longevity

Ke M

Tue Dec 27 00:00:00 EST 2022

EV71 3C protease cleaves host anti-viral factor OAS3 and enhances virus replication.

Virologica Sinica

Zhou X,Tian L,Wang J,Zheng B,Zhang W

Wed Jun 01 00:00:00 EDT 2022

OAS1, OAS2, and OAS3 Contribute to Epidermal Keratinocyte Proliferation by Regulating Cell Cycle and Augmenting IFN-1‒Induced Jak1‒Signal Transducer and Activator of Transcription 1 Phosphorylation in Psoriasis.

The Journal of investigative dermatology

Huang YZ,Zheng YX,Zhou Y,Xu F,Cui YZ,Chen XY,Wang ZY,Yan BX,Zheng M,Man XY

Sat Oct 01 00:00:00 EDT 2022

IFN-β1b induces OAS3 to inhibit EV71 via IFN-β1b/JAK/STAT1 pathway.

Virologica Sinica

Zheng B,Zhou X,Tian L,Wang J,Zhang W

Sat Oct 01 00:00:00 EDT 2022

Deficiency of ER Ca²⁺ sensor STIM1 in AgRP neurons confers protection against dietary obesity.

Cell reports

Chen Z,Pan S,Yin K,Zhang Y,Yuan X,Wang S,Yang S,Shen Q,Tang Y,Li J,Wang Y,Lu Y,Zhang G

Tue Oct 19 00:00:00 EDT 2021

Identification of potential immune-related circRNA-miRNA-mRNA regulatory network in cutaneous squamous cell carcinoma.

American journal of cancer research

Wei Y,Yang X,Gao L,Yang J,Zheng L,Gao L,Zhou X,Xiang X,Zhang J,Yi C

Sat Nov 13 00:00:00 EST 2021

Large-scale and high-resolution mass spectrometry-based proteomics profiling defines molecular subtypes of esophageal cancer for therapeutic targeting.

Nature communications

Liu W,Xie L,He YH,Wu ZY,Liu LX,Bai XF,Deng DX,Xu XE,Liao LD,Lin W,Heng JH,Xu X,Peng L,Huang QF,Li CY,Zhang ZD,Wang W,Zhang GR,Gao X,Wang SH,Li CQ,Xu LY,Liu W,Li EM

Mon Aug 16 00:00:00 EDT 2021

A prenylated dsRNA sensor protects against severe COVID-19.

Science (New York, N.Y.)

Wickenhagen A,Sugrue E,Lytras S,Kuchi S,Noerenberg M,Turnbull ML,Loney C,Herder V,Allan J,Jarmson I,Cameron-Ruiz N,Varjak M,Pinto RM,Lee JY,Iselin L,Palmalux N,Stewart DG,Swingler S,Greenwood EJD,Crozier TWM,Gu Q,Davies EL,Clohisey S,Wang B,Trindade Maranhão Costa F,Freire Santana M,de Lima Ferreira LC,Murphy L,Fawkes A,Meynert A,Grimes G,Da Silva Filho JL,Marti M,Hughes J,Stanton RJ,Wang ECY,Ho A,Davis I,Jarrett RF,Castello A,Robertson DL,Semple MG,Openshaw PJM,Palmarini M,Lehner PJ,Baillie JK,Rihn SJ,Wilson SJ

Fri Oct 29 00:00:00 EDT 2021

Inhibition of cGAS-Mediated Interferon Response Facilitates Transgene Expression.

iScience

Fu Y,Fang Y,Lin Z,Yang L,Zheng L,Hu H,Yu T,Huang B,Chen S,Wang H,Xu S,Bao W,Chen Q,Sun L

Fri Apr 24 00:00:00 EDT 2020

Bioinformatics

Protein Aliases: (2-5')oligo(A) synthase 3; (2-5')oligo(A) synthetase 3; 2'-5'-oligoadenylate synthase 3; 2'-5'-oligoadenylate synthetase 3, 100kDa; 2'-5'oligoadenylate synthetase p100; 2-5A synthase 3; 2-5A synthetase 3; p100 OAS; p100OAS

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Gene Aliases: OAS3; P/OKcl.4; p100; p100OAS

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UniProt ID: (Human) Q9Y6K5

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Entrez Gene ID: (Human) 4940

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Function(s)

2'-5'-oligoadenylate synthetase activity double-stranded RNA binding protein binding ATP binding metal ion binding nucleotidyltransferase

Process(es)

nucleobase-containing compound metabolic process response to virus negative regulation of viral genome replication defense response to virus interferon-gamma-mediated signaling pathway type I interferon signaling pathway regulation of ribonuclease activity

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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OAS3 Polyclonal Antibody

OAS3 Antibody (21915-1-AP) in ICC/IF

Product Details

21915-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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