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Product Details
PA5-111455
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein corresonding to Human OLFM1. Recombinant protein control fragment (Product #RP-101266).
Conjugate
Form
Liquid
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2856865
Product Specific Information
Immunogen sequence: IEVLDRRTQR DLQYVEKMEN QMKGLESKFK QVEESHKQHL ARQFKAIKAK MDE
Target Information
The Olfactomedin family comprises a diverse group of secreted glycoproteins, which includes OLFM1 (Noelin-1), OLFM2 (Noelin-2), OLFM3 (Noelin-3), OLFM4 (Noelin-4), tiarin, pancortin, gliomedin and mycocilin. These proteins are implicated in the development of the nervous system. Specifically, OLFM1 and OLFM2 expression is observed in the neural plate and neural crest, as well as in the cranial ganglia in mouse at E8-10, and later in brain tissue and in the zone of polarizing activity in the limb. Overexpression of OLFM1 causes an excess of neural crest emigrations and prolonged neural crest production. OLFM2 participates in the regulation of the development of the anterior nervous system. An Arg144Gln mutation in OLFM2 has been implicated as a possible cause for open-angle glaucoma (OAG).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: neuroblastoma protein; Neuronal olfactomedin-related ER localized protein; Noelin; olfactomedin related ER localized protein; Olfactomedin-1; pancortin 1
Gene Aliases: AMY; NOE1; NOEL1; NOELIN1; OlfA; OLFM1
UniProt ID: (Human) Q99784
Entrez Gene ID: (Human) 10439
atrioventricular valve formation
nervous system development
positive regulation of gene expression
negative regulation of gene expression
positive regulation of epithelial to mesenchymal transition
neuronal signal transduction
regulation of axon extension
cardiac epithelial to mesenchymal transition
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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