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Product Details
MA5-23805
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Mouse
/ IgG2A
Class
Monoclonal
Type
Antibody
Clone
257224
Immunogen
E. coli-derived recombinant human Olig1 (aa 1-272)
Conjugate
Form
Lyophilized
Concentration
0.5 mg/mL
Purification
Protein A/G
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2607923
Product Specific Information
In direct ELISAs, this antibody shows approximately 20% cross-reactivity with recombinant human (rh) Olig2 and 50-100% cross-reactivity with rhOlig3.
Reconstitute at 0.5 mg/mL in sterile PBS.
Target Information
Olig1 promotes formation and maturation of oligodendrocytes, especially within the brain. Cooperates with OLIG2 to establish the pMN domain of the embryonic neural tube. Olig2 is an essential regulator of ventral neuroectodermal progenitor cell fate. The gene is involved in a chromosomal translocation t(14;21)(q11.2;q22) associated with T-cell acute lymphoblastic leukemia. Its chromosomal location is within a region of chromosome 21 which has been suggested to play a role in learning deficits associated with Down syndrome. Tissue specificity: Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas highly variable.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: basic domain, helix-loop-helix protein, class B, 1; basic domain, helix-loop-helix protein, class B, 6; bHLHb1; bHLHb6; bHLHb7; bHLHe19; bHLHe20; bHLHe21; Class B basic helix-loop-helix protein 1; Class B basic helix-loop-helix protein 6; Class B basic helix-loop-helix protein 7; Class E basic helix-loop-helix protein 19; Class E basic helix-loop-helix protein 20; Class E basic helix-loop-helix protein 21; human protein kinase C-binding protein RACK17; olig-2; Oligo1; Oligo2; Oligo2 antibody; Oligo3; oligodendrocyte lineage transcription factor 1; Oligodendrocyte transcription factor 1; Oligodendrocyte transcription factor 2; Oligodendrocyte transcription factor 3; oligodendrocyte-specific bHLH transcription factor 1; oligodendrocyte-specific bHLH transcription factor 2; Protein kinase C-binding protein 2; Protein kinase C-binding protein RACK17
Gene Aliases: BHLHB1; BHLHB6; BHLHB7; BHLHE19; BHLHE20; BHLHE21; OLIG1; OLIG2; OLIG3; OLIGO2; PRKCBP2; RACK17
UniProt ID: (Human) Q8TAK6, (Human) Q13516, (Human) Q7RTU3
Entrez Gene ID: (Human) 116448, (Human) 10215, (Human) 167826
DNA binding
protein binding
protein dimerization activity
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
protein homodimerization activity
HMG box domain binding
RNA polymerase II transcription corepressor activity
basic helix-loop-helix transcription factor
transcription, DNA-templated
regulation of transcription, DNA-templated
neuron fate commitment
oligodendrocyte differentiation
negative regulation of transcription from RNA polymerase II promoter
spinal cord motor neuron differentiation
spinal cord oligodendrocyte cell fate specification
thalamus development
myelination
negative regulation of neuron differentiation
positive regulation of oligodendrocyte differentiation
spinal cord motor neuron cell fate specification
spinal cord motor neuron migration
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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