Proteintech

OLIG2 Monoclonal Antibody (1E8C5)

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OLIG2 Antibody (66513-1-IG) in WB

Human cerebellum tissue were subjected to SDS PAGE followed by western blot with 66513-1-Ig (OLIG2 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours.

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Product Details

66513-1-IG

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:6,000

View 4 publications 4 publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunocytochemistry (ICC/IF)

View 8 publications 8 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

1E8C5

Immunogen

OLIG2 Fusion Protein Ag18838 (1-323 aa encoded by BC047511)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MDSDASLVS SRPSSPEPDD LFLPARSKGS SGSAFTGGTV SSSTPSDCPP ELSAELRGAM GSAGAHPGDK LGGSGFKSSS SSTSSSTSSA AASSTKKDKK QMTEPELQQL RLKINSRERK RMHDLNIAMD GLREVMPYAH GPSVRKLSKI TTLLLARNYI LMLTNSLEEM KRLVSEIYGG HHAGFHPSAC GGLAHSAPLP AATAHPAAAA HAAHHPAVHH PILPPAAAAA AAAAAAAAVS SASLPGSGLP SVGSIRPPHG LLKSPSAAAA APLGGGGGGS GASGGFQHWG GMPCPCSMCQ VPPPHHHVSA MGAGSLPRLT SDAK (1-323 aa encoded by BC047511)

Target Information

This gene encodes a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain. The protein is an essential regulator of ventral neuroectodermal progenitor cell fate. The gene is involved in a chromosomal translocation t(14;21)(q11.2;q22) associated with T-cell acute lymphoblastic leukemia. Its chromosomal location is within a region of chromosome 21 which has been suggested to play a role in learning deficits associated with Down syndrome. Tissue specificity: Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas highly variable.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

A bio-orthogonal linear ubiquitin probe identifies STAT3 as a direct substrate of OTULIN in glioblastoma.

Nucleic acids research

Du X,Pang J,Gu B,Si T,Chang Y,Li T,Wu M,Wang Z,Wang Y,Feng J,Wu N,Man J,Li H,Li A,Zhang T,Wang B,Duan X

Wed Feb 22 00:00:00 EST 2023

Remyelination in neuromyelitis optica spectrum disorder is promoted by edaravone through mTORC1 signaling activation.

Glia

Luo W,Xu H,Xu L,Jiang W,Chen C,Chang Y,Liu C,Tian Z,Qiu X,Xie C,Li X,Chen H,Lai S,Wu L,Cui Y,Tang C,Qiu W

Wed Feb 01 00:00:00 EST 2023

Novel Alzheimer risk factor IQ motif containing protein K is abundantly expressed in the brain and is markedly increased in patients with Alzheimer's disease.

Frontiers in cellular neuroscience

Wang H,Devadoss D,Nair M,Chand HS,Lakshmana MK

Sat Aug 06 00:00:00 EDT 2022

Novel Alzheimer risk factor IQ motif containing protein K is abundantly expressed in the brain and is markedly increased in patients with Alzheimer's disease.

Frontiers in cellular neuroscience

Wang H,Devadoss D,Nair M,Chand HS,Lakshmana MK

Sat Aug 06 00:00:00 EDT 2022

Novel Alzheimer risk factor IQ motif containing protein K is abundantly expressed in the brain and is markedly increased in patients with Alzheimer's disease.

Frontiers in cellular neuroscience

Wang H,Devadoss D,Nair M,Chand HS,Lakshmana MK

Sat Aug 06 00:00:00 EDT 2022

Novel Alzheimer risk factor IQ motif containing protein K is abundantly expressed in the brain and is markedly increased in patients with Alzheimer's disease.

Frontiers in cellular neuroscience

Wang H,Devadoss D,Nair M,Chand HS,Lakshmana MK

Sat Aug 06 00:00:00 EDT 2022

Effect of β-hydroxybutyrate on behavioral alterations, molecular and morphological changes in CNS of multiple sclerosis mouse model.

Frontiers in aging neuroscience

Sun W,Wen M,Liu M,Wang Q,Liu Q,Li L,Siebert HC,Loers G,Zhang R,Zhang N

Thu Dec 22 00:00:00 EST 2022

Effect of β-hydroxybutyrate on behavioral alterations, molecular and morphological changes in CNS of multiple sclerosis mouse model.

Frontiers in aging neuroscience

Sun W,Wen M,Liu M,Wang Q,Liu Q,Li L,Siebert HC,Loers G,Zhang R,Zhang N

Thu Dec 22 00:00:00 EST 2022

A three-dimensional matrix system containing melatonin and neural stem cells repairs damage from traumatic brain injury in rats.

Neural regeneration research

Fang XY,Zhao DW,Zhang C,Ge HF,Zhang XY,Zhao FC,Jiang YB,Feng H,Hu R

Tue Nov 01 00:00:00 EDT 2022

Prognostic Value and Biological Function of Galectins in Malignant Glioma.

Frontiers in oncology

Zhu H,Liu D,Cheng L,Liu J,Wang G,Li H,Zhang Y,Mi H,Zhang S,Shu K,Yu X

Sat Jul 16 00:00:00 EDT 2022

Hypoxia-induced HMGB1 promotes glioma stem cells self-renewal and tumorigenicity via RAGE.

iScience

Ye C,Li H,Li Y,Zhang Y,Liu G,Mi H,Li H,Xiao Q,Niu L,Yu X

Fri Sep 16 00:00:00 EDT 2022

Hypoxia-induced HMGB1 promotes glioma stem cells self-renewal and tumorigenicity via RAGE.

iScience

Ye C,Li H,Li Y,Zhang Y,Liu G,Mi H,Li H,Xiao Q,Niu L,Yu X

Fri Sep 16 00:00:00 EDT 2022

Single-Cell RNA Sequencing With Combined Use of Bulk RNA Sequencing to Reveal Cell Heterogeneity and Molecular Changes at Acute Stage of Ischemic Stroke in Mouse Cortex Penumbra Area.

Frontiers in cell and developmental biology

Guo K,Luo J,Feng D,Wu L,Wang X,Xia L,Tao K,Wu X,Cui W,He Y,Wang B,Zhao Z,Zhang Z

Fri Mar 12 00:00:00 EST 2021

Shenzhiling oral liquid protects the myelin sheath against Alzheimer's disease through the PI3K/Akt-mTOR pathway.

Journal of ethnopharmacology

Zheng M,Liu Z,Mana L,Qin G,Huang S,Gong Z,Tian M,He Y,Wang P

Tue Oct 05 00:00:00 EDT 2021

Role of TREM-1 in the development of early brain injury after subarachnoid hemorrhage.

Experimental neurology

Sun XG,Zhang MM,Liu SY,Chu XH,Xue GQ,Zhang BC,Zhu JB,Godje Godje IS,Zhu LJ,Hu HY,Shen YJ,Wang GQ

Thu Jul 01 00:00:00 EDT 2021

Matrine protects oligodendrocytes by inhibiting their apoptosis and enhancing mitochondrial autophagy.

Brain research bulletin

Wang MR,Zhang XJ,Liu HC,Ma WD,Zhang ML,Zhang Y,Li X,Dou MM,Jing YL,Chu YJ,Zhu L

Fri Nov 01 00:00:00 EDT 2019

Bioinformatics

Protein Aliases: basic domain, helix-loop-helix protein, class B, 1; Basic helix loop helix protein class B1 (bHLHB1); basic helix-loop-helix protein 19 (bHLHe19); bHLHb1; bHLHe19; Class B basic helix-loop-helix protein 1; Class E basic helix-loop-helix protein 19; human protein kinase C-binding protein RACK17; olig-2; Oligo2; Oligo2 antibody; Oligodendrocyte specific bHLH transcription factor 2; Oligodendrocyte transcription factor 2; oligodendrocyte-specific bHLH transcription factor 2; Protein kinase C-binding protein 2; Protein kinase C-binding protein 2 (PRKCBP2); Protein kinase C-binding protein RACK17

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Gene Aliases: AI604895; BHLHB1; BHLHE19; Olg-2; OLIG2; OLIGO2; PRKCBP2; RACK17; RK17

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UniProt ID: (Human) Q13516, (Mouse) Q9EQW6

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Entrez Gene ID: (Human) 10215, (Mouse) 50913, (Rat) 304103

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Function(s)

DNA binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding protein homodimerization activity HMG box domain binding transcription factor activity, sequence-specific DNA binding protein binding protein dimerization activity basic helix-loop-helix transcription factor

Process(es)

negative regulation of transcription from RNA polymerase II promoter transcription, DNA-templated spinal cord motor neuron differentiation spinal cord oligodendrocyte cell fate specification thalamus development myelination negative regulation of neuron differentiation neuron fate commitment positive regulation of oligodendrocyte differentiation regulation of transcription, DNA-templated transcription from RNA polymerase II promoter multicellular organism development nervous system development spinal cord oligodendrocyte cell differentiation oligodendrocyte differentiation

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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OLIG2 Monoclonal Antibody (1E8C5)

OLIG2 Antibody (66513-1-IG) in WB

Product Details

66513-1-IG

Western Blot (WB)

Immunohistochemistry (IHC)

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Clone

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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