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Product Details
MA5-55294
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
2D7A3
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 354-388 of human Mu Opioid Receptor(MOR).
Conjugate
Form
Liquid
Concentration
1.07 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 0.05% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Dry ice (international)
Product Specific Information
Immunogen Sequence: IPTSSNIEQQ NSTRIRQNTR DHPSTANTVD RTNHQ
Target Information
The OPRM1 gene encodes the mu opioid receptor, which is the primary site of action for the most commonly used opioids, including morphine, heroin, fentanyl, and methadone. It is also the primary receptor for endogenous opioid peptides beta-endorphin and the enkephalins. The OPRM1 receptor is a membrane of the G protein-coupled receptor family. There are at least 3 types of opioid receptors, mu, kappa, and delta, each with a distinct pharmacologic profile.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: hMOP; KIAA0403; M-OR-1; MOP receptor; MOR-1C; mu opioid receptor splice variant mMOR-1Z; Mu-type opioid receptor; Opioid mu receptor; Opioid Receptor; OTTHUMP00000017463
Gene Aliases: M-OR-1; MOP-R; Mor; MOR-1; MOR-1O; muOR; Oprm; Oprm1
UniProt ID: (Mouse) P42866
Entrez Gene ID: (Mouse) 18390
G-protein alpha-subunit binding
signal transducer activity
G-protein coupled receptor activity
beta-endorphin receptor activity
opioid receptor activity
voltage-gated calcium channel activity
protein binding
protein C-terminus binding
protein domain specific binding
filamin binding
G-protein beta-subunit binding
morphine receptor activity
neuropeptide binding
G-protein coupled receptor
transmembrane signal receptor
signal transduction
G-protein coupled receptor signaling pathway
adenylate cyclase-activating dopamine receptor signaling pathway
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
negative regulation of adenylate cyclase activity
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
neuropeptide signaling pathway
chemical synaptic transmission
locomotory behavior
sensory perception of pain
negative regulation of cAMP biosynthetic process
adenylate cyclase-inhibiting opioid receptor signaling pathway
positive regulation of appetite
cellular response to stress
opioid receptor signaling pathway
eating behavior
positive regulation of cAMP-mediated signaling
negative regulation of cAMP-mediated signaling
negative regulation of nitric oxide biosynthetic process
positive regulation of nitric oxide biosynthetic process
response to ethanol
behavioral response to ethanol
positive regulation of neurogenesis
negative regulation of cytosolic calcium ion concentration
regulation of sensory perception of pain
excitatory postsynaptic potential
negative regulation of Wnt protein secretion
positive regulation of ERK1 and ERK2 cascade
calcium ion transmembrane transport
cellular response to morphine
regulation of N-methyl-D-aspartate selective glutamate receptor activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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