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Product Details
60293-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Not Applicable
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
6C1H4
Immunogen
OPTN Fusion Protein Ag1272 (233-577 aa encoded by BC013876)
Conjugate
Form
Liquid
Concentration
1.7 mg/mL
Purification
Protein G
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: VSQLLLCLR EGNQKVERLE VALKEAKERV SDFEKKTSNR SEIETQTEGS TEKENDEEKG PETVGSEVEA LNLQVTSLFK ELQEAHTKLS EAELMKKRLQ EKCQALERKN SAIPSELNEK QELVYTNKKL ELQVESMLSE IKMEQAKTED EKSKLTVLQM THNKLLQEHN NALKTIEELT RKESEKVDRA VLKELSEKLE LAEKALASKQ LQMDEMKQTI AKQEEDLETM TILRAQMEVY CSDFHAERAA REKIHEEKEQ LALQLAVLLK ENDAFEDGGR QSLMEMQSRH GARTSDSDQQ AYLVQRGAED RDWRQQRNIP IHSCPKCGEV LPDIDTLQIH VMDCII (233-577 aa encoded by BC013876)
Target Information
This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14. 7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Ag9 C5; E3-14.7K-interacting protein; FIP 2; FIP-2; HIP 7; HIP-7; Huntingtin interacting protein L; Huntingtin yeast partner L; Huntingtin-interacting protein 7; Huntingtin-interacting protein L; NEMO-related protein; Optic neuropathy-inducing protein; Optineurin; TFIIIA IntP; TFIIIA-IntP; Transcription factor IIIA-interacting protein; transcrption factor IIIA-interacting protein; tumor necrosis factor alpha-inducible cellular protein containing leucine zipper domains; Uban
Gene Aliases: ALS12; FIP2; GLC1E; HIP7; HYPL; NRP; OPTN; TFIIIA-INTP
UniProt ID: (Human) Q96CV9
Entrez Gene ID: (Human) 10133
protein targeting to Golgi
G2/M transition of mitotic cell cycle
negative regulation of receptor recycling
Golgi organization
signal transduction
cell death
macroautophagy
Golgi to plasma membrane protein transport
regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of I-kappaB kinase/NF-kappaB signaling
defense response to Gram-negative bacterium
parkin-mediated mitophagy in response to mitochondrial depolarization
Golgi ribbon formation
xenophagy
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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