Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Immunogen sequence: FETPDQGKARL LTHWEQLDYG VQFTSSR
Highest antigen sequence identity to the following orthologs - mouse 96%, rat 93%.
The ORMDL (ORM1-like) family of proteins consist of ORMDL1, ORMDL2 and ORMDL3 that may play roles in -gamma-secretase complex maturation. Localized to the membrane of the endoplasmic reticulum, ORMDLs are widely expressed and are implicated in the expression of Presenilin (PSI) which is involved in Alzheimer's disease (AD). Expression of ORMDL1 is down-regulated in PSI mutations, suggesting a possible role as a therapeutic target for AD. ORMDLs have recently been identified as a potential risk factor for childhood asthma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Adoplin-1; ORM1-like protein 1
Gene Aliases: HSPC202; ORMDL1
UniProt ID: (Human) Q9P0S3
Entrez Gene ID: (Human) 94101
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