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Invitrogen
OTUB1 Polyclonal Antibody
Advanced Verification
This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated.
Product Details
PA5-58684
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human OTUB1. Recombinant protein control fragment (Product #RP-95850).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2645113
Product Specific Information
Immunogen sequence: AAEEPQQQKQ EPLGSDSEGV NCLAYDEAIM AQQDRIQQEI AVQNPLVSER LELSVLYKEY AEDDNIYQQK IKDLHKKYSY IRKTRPD
Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 100%.
Target Information
The product of this gene is a member of the OTU superfamily of predicted cysteine proteases. The encoded protein is a highly specific ubiquitin iso-peptidase, and cleaves ubiquitin from branched poly-ubiquitin chains but not from ubiquitinated substrates. It interacts with another ubiquitin protease and an E3 ubiquitin ligase that inhibits cytokine gene transcription in the immune system. It is proposed to function in specific ubiquitin-dependent pathways, possibly by providing an editing function for polyubiquitin chain growth. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Deubiquitinating enzyme OTUB1; deubiquitinating enzyme OTUB1 {ECO:0000250|UniProtKB:Q7TQI3}; FLJ20113; FLJ40710; hOTU1; MGC111158; MGC4584; OTU domain, ubiquitin aldehyde binding 1; OTU domain-containing ubiquitin aldehyde-binding protein 1; OTU domain-containing ubiquitin aldehyde-binding protein 1 {ECO:0000250|UniProtKB:Q7TQI3}; OTU-domain Ubal-binding 1; otub1 {ECO:0000312|EMBL:AAI66771.1}; otubain 1; Otubain-1; otubain-1 {ECO:0000250|UniProtKB:Q7TQI3}; Ubiquitin thioesterase OTUB1; ubiquitin thioesterase OTUB1 {ECO:0000250|UniProtKB:Q7TQI3}; ubiquitin-specific protease otubain 1; Ubiquitin-specific-processing protease OTUB1; ubiquitin-specific-processing protease OTUB1 {ECO:0000250|UniProtKB:Q7TQI3}
Gene Aliases: AI850305; HSPC263; OTB1; OTU1; OTUB1
UniProt ID: (Human) Q96FW1, (Mouse) Q7TQI3, (Rat) B2RYG6
Entrez Gene ID: (Human) 55611, (Mouse) 107260, (Rat) 293705
adaptive immune response
DNA repair
cellular response to DNA damage stimulus
protein K48-linked deubiquitination
cellular response to interleukin-1
negative regulation of histone H2A K63-linked ubiquitination
negative regulation of double-strand break repair
immune system process
proteolysis
protein deubiquitination
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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