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Product Details
PA5-44953
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide directed towards the middle region of human TNFSF4
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2609149
Product Specific Information
Peptide sequence: QEVNISLHYQ KDEEPLFQLK KVRSVNSLMV ASLTYKDKVY LNVTTDNTSL
Sequence homology: Human: 100%
Target Information
The tumor necrosis factor superfamily member TNFSF4 is a type II membrane bound, non-covalently linked homotrimeric protein. It is expressed on antigen presenting cells, such as dendritic cells and activated B-cells, and also on other cells such as vascular endothelial cells, mast cells, and natural killer cells. TNFSF4 signals specifically through the TNFRSF4 receptor, is expressed predominantly on CD4+T cells but also on certain activated CD8+T cells. TNFRSF4/TNFSF4 functions as a costimulatory signal, which is required for a productive interaction between antigen presenting cells and their target T-cells. It enhances cell proliferation and survival, and increases expression of RANTES, IL-2, IL-3, and IFNgamma. TNFRSF4/TNFSF4 signaling plays an important role in immunotolerance.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD134 ligand; CD252; Glycoprotein Gp34; OX40 antigen ligand; OX40 ligand; OX40L; TAX transcriptionally-activated glycoprotein 1; tax-transcriptionally activated glycoprotein 1 (34kD); tumor necrosis factor (ligand) superfamily member 4; tumor necrosis factor ligand 2B; Tumor necrosis factor ligand superfamily member 4
Gene Aliases: CD134L; CD252; GP34; OX-40L; OX4OL; TNFSF4; TNLG2B; TXGP1
UniProt ID: (Human) P23510
Entrez Gene ID: (Human) 7292
defense response to nematode
acute inflammatory response
positive regulation of T cell cytokine production
regulation of adaptive immune response
positive regulation of type 2 immune response
positive regulation of immunoglobulin mediated immune response
immune response
signal transduction
cholesterol metabolic process
positive regulation of cell proliferation
response to virus
negative regulation of interferon-gamma production
negative regulation of interleukin-17 production
positive regulation of interferon-gamma production
positive regulation of interleukin-10 production
positive regulation of interleukin-12 production
positive regulation of interleukin-13 production
positive regulation of interleukin-2 production
positive regulation of interleukin-4 production
positive regulation of interleukin-6 production
tumor necrosis factor-mediated signaling pathway
memory T cell activation
T-helper 2 cell activation
response to nitrogen dioxide
cellular response to nitrogen dioxide
CD4-positive, alpha-beta T cell costimulation
T cell proliferation
positive regulation of T cell proliferation
positive regulation of activated T cell proliferation
positive regulation of CD4-positive, alpha-beta T cell differentiation
positive regulation of memory T cell differentiation
negative regulation of sequence-specific DNA binding transcription factor activity
negative regulation of regulatory T cell differentiation
negative regulation of T-helper 1 cell differentiation
positive regulation of T-helper 2 cell differentiation
negative regulation of transcription, DNA-templated
positive regulation of alpha-beta T cell proliferation
negative regulation of cytokine secretion
regulation of inflammatory response
positive regulation of inflammatory response
positive regulation of B cell activation
positive regulation of immunoglobulin secretion
cellular response to lipopolysaccharide
cellular response to prostaglandin E stimulus
chemokine (C-C motif) ligand 11 production
positive regulation of CD4-positive, alpha-beta T cell costimulation
positive regulation of memory T cell activation
positive regulation of T-helper 2 cell activation
positive regulation of interleukin-4-dependent isotype switching to IgE isotypes
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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