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Product Details
PA5-46885
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse OX40 Ligand/TNFSF4 Gln49-Leu198
Conjugate
Excitation/Emission Max
565/576 nm
View spectra
Form
Liquid
Purification
Antigen affinity chromatography
Storage buffer
Buffered saline solution with BSA
Contains
0.09% sodium azide
Storage conditions
4° C, store in dark, DO NOT FREEZE!
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2608756
Product Specific Information
In Western blots, approximately 5% cross-reactivity with recombinant human (rh) OX40 Ligand, rhLIGHT, recombinant mouse (rm) Fas Ligand and less than 1% cross-reactivity with rmTNF- alpha, rhGITR Ligand, rhTRANCE, and rhVEGI is observed.
Target Information
The tumor necrosis factor superfamily member TNFSF4 is a type II membrane bound, non-covalently linked homotrimeric protein. It is expressed on antigen presenting cells, such as dendritic cells and activated B-cells, and also on other cells such as vascular endothelial cells, mast cells, and natural killer cells. TNFSF4 signals specifically through the TNFRSF4 receptor, is expressed predominantly on CD4+T cells but also on certain activated CD8+T cells. TNFRSF4/TNFSF4 functions as a costimulatory signal, which is required for a productive interaction between antigen presenting cells and their target T-cells. It enhances cell proliferation and survival, and increases expression of RANTES, IL-2, IL-3, and IFNgamma. TNFRSF4/TNFSF4 signaling plays an important role in immunotolerance.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: atherosclerosis 1; CD252; OX40 ligand; OX40L; tax-transcriptionally activated glycoprotein 1 ligand; Tumor necrosis factor ligand superfamily member 4
Gene Aliases: Ath-1; Ath1; CD134L; gp34; OX-40L; Ox40l; Tnfsf4; TXGP1; Txgp1l
UniProt ID: (Mouse) P43488
Entrez Gene ID: (Mouse) 22164
blood vessel development
cytokine production
defense response to nematode
acute inflammatory response
positive regulation of immune effector process
positive regulation of T cell cytokine production
regulation of adaptive immune response
positive regulation of type 2 immune response
positive regulation of immunoglobulin mediated immune response
inflammatory response
immune response
cholesterol metabolic process
response to virus
negative regulation of interferon-gamma production
negative regulation of interleukin-17 production
positive regulation of interferon-gamma production
positive regulation of interleukin-10 production
positive regulation of interleukin-12 production
positive regulation of interleukin-13 production
positive regulation of interleukin-2 production
positive regulation of interleukin-4 production
positive regulation of interleukin-6 production
memory T cell activation
T-helper 2 cell activation
response to nitrogen dioxide
cellular response to nitrogen dioxide
CD4-positive, alpha-beta T cell costimulation
T cell proliferation
positive regulation of activated T cell proliferation
positive regulation of CD4-positive, alpha-beta T cell differentiation
positive regulation of memory T cell differentiation
negative regulation of sequence-specific DNA binding transcription factor activity
innate immune response
negative regulation of regulatory T cell differentiation
negative regulation of T-helper 1 cell differentiation
positive regulation of T-helper 2 cell differentiation
negative regulation of transcription, DNA-templated
positive regulation of alpha-beta T cell proliferation
negative regulation of cytokine secretion
regulation of inflammatory response
positive regulation of inflammatory response
positive regulation of B cell activation
positive regulation of immunoglobulin secretion
negative regulation of T cell apoptotic process
negative regulation of activation-induced cell death of T cells
cellular response to lipopolysaccharide
cellular response to prostaglandin E stimulus
chemokine (C-C motif) ligand 11 production
positive regulation of CD4-positive, alpha-beta T cell costimulation
positive regulation of T cell migration
positive regulation of T cell costimulation
positive regulation of memory T cell activation
positive regulation of T-helper 2 cell activation
positive regulation of interleukin-4-dependent isotype switching to IgE isotypes
negative regulation of extrinsic apoptotic signaling pathway
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