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Invitrogen
Orexin A Polyclonal Antibody
FIGURE: 1 / 1
Orexin A Antibody (PA1-18310) in ICC/IF
Scientific reports 2021 -
Figure 1 Parental nursing behaviour activates MCH neuron in the LHA and cell-specific ablation of MCH neurons impairs nursing behaviour in both virgin female and male mice. ( a ) Simultaneous visualisation of c-fos - and MCH-immunoreactive (ir) cells in coronal brain sections at the level of the LHA. Scale bars are 100 um in the above and 20 um in the bottom; a square indicates place of bottom figures in th... View More
Product Details
PA1-18310
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Rat
Published species
Not Applicable
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to residues C(14) R L Y E L L H G A G N H A A G I L T L(33) of Bovin Orexin A, conjugated to KLH.
Conjugate
Form
Lyophilized
Concentration
Conc. Not Determined
Storage buffer
whole serum
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2279679
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material. After reconstitution keep aliquots at -20 °C for a higher stability, and at 4 °C with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles.
Target Information
This gene encodes a hypothalamic neuropeptide precursor protein that gives rise to two mature neuropeptides, orexin A and orexin B, by proteolytic processing. Orexin A and orexin B, which bind to orphan G-protein coupled receptors HCRTR1 and HCRTR2, function in the regulation of sleep and arousal. This neuropeptide arrangement may also play a role in feeding behavior, metabolism, and homeostasis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Hcrt; hcrt1; Hypocretin; Hypocretin (orexin) neuropeptide; Hypocretin neuropeptide precursor; hypocretin-1; orexin; Orexin precursor; Prepro-orexin; Preprohypocretin
Gene Aliases: HCRT; orexin-A; OX; PPOX
UniProt ID: (Bovine) P56717, (Rat) O55232
Entrez Gene ID: (Bovine) 281222, (Rat) 25723
neuropeptide signaling pathway
temperature homeostasis
behavioral fear response
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
protein kinase C-activating G-protein coupled receptor signaling pathway
feeding behavior
negative regulation of DNA replication
eating behavior
negative regulation of potassium ion transport
regulation of neurotransmitter secretion
release of sequestered calcium ion into cytosol
positive regulation of calcium ion transport
negative regulation of transmission of nerve impulse
positive regulation of transmission of nerve impulse
excitatory postsynaptic potential
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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