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Product Details
PA1-85744
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Sheep
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to amino acids P(2) L P D C C R Q K T C S C(14) of human orexin A conjugated to KLH.
Conjugate
Form
Liquid
Concentration
5 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.2
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2117626
Product Specific Information
Predicted to react with bovine, chimpanzee, dog, horse, mouse, pig, rabbit, rat and rhesus monkey based on sequence homology.
Hypothalamus tissue can be used as a positive control.
Sheep anti Human orexin A antibody recognizes human orexin A, an excitatory neuropeptide linked to alertness and wakefulness in humans.
Target Information
This gene encodes a hypothalamic neuropeptide precursor protein that gives rise to two mature neuropeptides, orexin A and orexin B, by proteolytic processing. Orexin A and orexin B, which bind to orphan G-protein coupled receptors HCRTR1 and HCRTR2, function in the regulation of sleep and arousal. This neuropeptide arrangement may also play a role in feeding behavior, metabolism, and homeostasis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Hcrt; Hypocretin; hypocretin (orexin) neuropeptide; Hypocretin neuropeptide precursor; Orexin precursor; Prepro-orexin; Preprohypocretin
Gene Aliases: HCRT; NRCLP1; OX; PPORX; PPOX
UniProt ID: (Human) O43612
Entrez Gene ID: (Human) 3060
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
protein kinase C-activating G-protein coupled receptor signaling pathway
neuropeptide signaling pathway
chemical synaptic transmission
negative regulation of DNA replication
eating behavior
negative regulation of potassium ion transport
regulation of neurotransmitter secretion
positive regulation of calcium ion transport
negative regulation of transmission of nerve impulse
positive regulation of transmission of nerve impulse
excitatory postsynaptic potential
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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