Invitrogen

Oxytocin Polyclonal Antibody

View all (12) Oxytocin antibodies
Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-120341

Applications
Tested Dilution
Publications

Western Blot (WB)

1:200-1:2,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 1-125 of human OXT (NP_000906.1).
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.95 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.01% thimerosal

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2913913

Product Specific Information

Positive test controls include: A549, NCI-H460, LO2, HepG2, Mouse liver, Rat liver, Rat lung. The target is usually found in the following locations: Secreted.

Immunogen sequence: MAGPSLACCL LGLLALTSAC YIQNCPLGGK RAAPDLDVRK CLPCGPGGKG RCFGPNICCA EELGCFVGTA EALRCQEENY LPSPCQSGQK ACGSGGRCAV LGLCCSPDGC HADPACDAEA TFSQR

Target Information

There are two proteins encoded by this gene, oxytocin and neurophysin I. Oxytocin is posterior pituitary hormone which is synthesized as an inactive precursor in the hypothalamus along with its carrier protein neurophysin I. Together with neurophysin, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis, where it is either stored or secreted into the bloodstream. The precursor seems to be activated while it is being transported along the axon to the posterior pituitary. This hormone contracts smooth muscle during parturition and lactation. It is also involved in cognition, tolerance, adaptation and complex sexual and maternal behaviour, as well as in the regulation of water excretion and cardiovascular functions.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: neurophysin 1; neurophysin I; OT-NPI; oxcytocin; oxytocin, prepro- (neurophysin I); oxytocin, prepropeptide; Oxytocin-neurophysin 1; oxytocin-neurophysin I, preproprotein; oxytocin/neurophysin (Oxt) gene, complete gene, complete cds

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Gene Aliases: OT; OT-NPI; OXT; OXT-NPI; Oxy

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UniProt ID: (Human) P01178, (Mouse) P35454, (Rat) P01179

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Entrez Gene ID: (Human) 5020, (Mouse) 18429, (Rat) 25504

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Function(s)
neurohypophyseal hormone activity oxytocin receptor binding hormone activity neuropeptide hormone activity protein binding neuropeptide
Process(es)
response to amphetamine regulation of heart rate maternal aggressive behavior signal transduction positive regulation of cytosolic calcium ion concentration heart development female pregnancy memory grooming behavior response to sucrose positive regulation of norepinephrine secretion response to activity sleep response to food positive regulation of prostaglandin secretion response to estradiol response to retinoic acid response to progesterone response to prostaglandin E social behavior negative regulation of urine volume positive regulation of renal sodium excretion response to cocaine hyperosmotic salinity response maternal behavior sperm ejaculation eating behavior drinking behavior response to peptide hormone response to ether negative regulation of blood pressure positive regulation of blood pressure positive regulation of ossification positive regulation of female receptivity positive regulation of synaptic transmission response to glucocorticoid response to cAMP response to electrical stimulus regulation of sensory perception of pain positive regulation of synapse assembly male mating behavior positive regulation of penile erection positive regulation of hindgut contraction negative regulation of gastric acid secretion positive regulation of uterine smooth muscle contraction response to organic cyclic compound regulation of digestive system process parturition lactation response to mechanical stimulus response to external biotic stimulus response to steroid hormone
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