Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
FIGURE: 1 / 1
Oxytocin Receptor Antibody (PA5-32961) in IHC (P)
Immunohistochemistry analysis of Oxytocin Receptor in human uterus, pregnant. Samples were incubated with Oxytocin Receptor polyclonal antibody (Product # PA5-32961). Formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Product Details
PA5-32961
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic 19 amino acid peptide from C-terminal cytoplasmic domain of human Oxytocin Receptor.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.1% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2550422
Product Specific Information
Percent identity with other species by BLAST analysis: Human (100%); Gorilla, Gibbon, Monkey (95%); Marmoset (89%); Mouse, Dog (84%).
For IHC(P), use heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.
Target Information
The oxytocin receptor (OXTR) belongs to the G-protein coupled receptor family. Its activity is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. The receptor is made up of 389 amino acids and has a molecular weight of ~43,000 kDa. The oxytocin-oxytocin receptor system plays an important role as an inducer of uterine contractions during parturition and of milk ejection. Oxytocin receptors are expressed by the myoepithelial cells of the mammary gland, and in both the myometrium and endometrium or the uterus at the end of pregnancy. Additionally, oxytocin receptors are present in the central nervous system, mediating a variety of behaviors, including maternal behavior, bonding, social memory and recognition, sexual and aggressive behaviors, and stress and anxiety.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: OT-R; Oxt-r; Oxytocin receptor
Gene Aliases: OT-R; OXTR
UniProt ID: (Human) P30559
Entrez Gene ID: (Human) 5021
suckling behavior
response to amphetamine
regulation of systemic arterial blood pressure by vasopressin
muscle contraction
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
heart development
female pregnancy
lactation
memory
positive regulation of norepinephrine secretion
telencephalon development
sleep
positive regulation of synaptic transmission, GABAergic
response to estradiol
response to progesterone
cellular response to hormone stimulus
response to anoxia
response to cytokine
social behavior
response to cocaine
response to drug
maternal behavior
sperm ejaculation
eating behavior
response to peptide hormone
estrous cycle
positive regulation of blood pressure
positive regulation of vasoconstriction
digestive tract development
positive regulation of synapse assembly
positive regulation of synaptic transmission, glutamatergic
maternal process involved in parturition
positive regulation of penile erection
negative regulation of gastric acid secretion
ERK1 and ERK2 cascade
positive regulation of uterine smooth muscle contraction
response to peptide
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support