Proteintech

P2RY12 Polyclonal Antibody

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P2RY12 Antibody (11976-1-AP) in WB

Human adrenal gland tissue were subjected to SDS PAGE followed by western blot with 11976-1-AP (P2RY12 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

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Product Details

11976-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:200-1:1,000

View 4 publications 4 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Not Applicable

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

P2RY12 Fusion Protein Ag2601 (1-342 aa encoded by BC017898)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.19 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MQAVDNLTS APGNTSLCTR DYKITQVLFP LLYTVLFFVG LITNGLAMRI FFQIRSKSNF IIFLKNTVIS DLLMILTFPF KILSDAKLGT GPLRTFVCQV TSVIFYFTMY ISISFLGLIT IDRYQKTTRP FKTSNPKNLL GAKILSVVIW AFMFLLSLPN MILTNRQPRD KNVKKCSFLK SEFGLVWHEI VNYICQVIFW INFLIVIVCY TLITKELYRS YVRTRGVGKV PRKKVNVKVF IIIAVFFICF VPFHFARIPY TLSQTRDVFD CTAENTLFYV KESTLWLTSL NACLDPFIYF FLCKSFRNSL ISMLKCPNSA TSLSQDNRKK EQDGGDPNEE TPM (1-342 aa encoded by BC017898)

Target Information

P2Y12 belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is involved in platelets aggregation, and is a potential target for the treatment of thromboembolisms and other clotting disorders. Two transcript variants encoding the same isoform have been identified for this gene. Expression of P2Y12 has been reported in platelets, spinal cord, and many brain regions. ESTs for P2Y12 have been isolated from B-cell/lung/testis, brain, embryo, prostate, eye, kidney carcinoma, and colon carcinoma libraries.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

HC067047 Ameliorates Sepsis-associated Encephalopathy by Suppressing Endoplasmic Reticulum Stress and Oxidative Stress-Induced Pyroptosis in the Hippocampi of Mice.

Neuroscience

Zhong X,Wang Y,Liu D,Liang Y,Liu W,Huang Y,Xie L,Cao W,Xu Y,Chen L

Mon May 01 00:00:00 EDT 2023

Multiplexed mRNA analysis of brain-derived extracellular vesicles upon experimental stroke in mice reveals increased mRNA content with potential relevance to inflammation and recovery processes.

Cellular and molecular life sciences : CMLS

Bub A,Brenna S,Alawi M,Kügler P,Gui Y,Kretz O,Altmeppen H,Magnus T,Puig B

Tue May 31 00:00:00 EDT 2022

Upregulation of P2Y12 inhibits chondrocyte apoptosis in lumbar osteoarthritis through the PI3K/AKT signaling pathway.

Molecular biology reports

Wu G,Xue P,Jin H,Zhang M,Gui C,Bao G,Xu G,Jiang J,Zhang J,Cui S,Cui Z,Sun Y

Fri Jul 01 00:00:00 EDT 2022

A recessive Trim2 mutation causes an axonal neuropathy in mice.

Neurobiology of disease

Li JJ,Sarute N,Lancaster E,Otkiran-Clare G,Fagla BM,Ross SR,Scherer SS

Wed Jul 01 00:00:00 EDT 2020

Bioinformatics

Protein Aliases: ADP-glucose receptor; ADPG-R; G-protein coupled receptor SP1999; Gi-coupled ADP receptor HORK3; P2T(AC); P2Y purinoceptor 12; P2Y(AC); P2Y(ADP); P2Y(cyc); P2Y12; P2Y12 platelet ADP receptor; P2YR12; purinergic receptor P2RY12; purinergic receptor P2Y, G-protein coupled, 12; putative G-protein coupled receptor; SP1999

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Gene Aliases: 2900079B22Rik; 4921504D23Rik; ADPG-R; BDPLT8; HORK3; P2RY12; P2T(AC); P2Y(12)R; P2Y(AC); P2Y(ADP); P2Y(cyc); P2Y12; SP1999

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UniProt ID: (Human) Q9H244, (Mouse) Q9CPV9, (Rat) Q9EPX4

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Entrez Gene ID: (Human) 64805, (Mouse) 70839, (Rat) 64803

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Function(s)

G-protein coupled adenosine receptor activity ADP receptor activity guanyl-nucleotide exchange factor activity signal transducer activity G-protein coupled receptor activity G-protein coupled purinergic nucleotide receptor activity G-protein coupled receptor

Process(es)

adenosine receptor signaling pathway substrate-dependent cell migration, cell extension G-protein coupled receptor signaling pathway adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway hemostasis glial cell migration negative regulation of norepinephrine secretion G-protein coupled purinergic nucleotide receptor signaling pathway positive regulation of ion transport protein kinase B signaling positive regulation of GTPase activity negative regulation of cell differentiation regulation of calcium ion transport platelet aggregation calcium ion transmembrane transport cellular response to ATP potassium ion transmembrane transport regulation of microglial cell migration signal transduction adenylate cyclase-modulating G-protein coupled receptor signaling pathway blood coagulation cell projection organization platelet activation cellular response to organic cyclic compound

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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P2RY12 Polyclonal Antibody

P2RY12 Antibody (11976-1-AP) in WB

Product Details

11976-1-AP

Western Blot (WB)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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