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P2X1 Receptor Antibody (APR-001-200UL) in IHC
Expression of P2X1 Receptor in rat hypothalamus - Immunohistochemical staining of rat supra-optic nucleus using Anti-P2X1 Receptor Antibody (#APR-001). P2X1 receptor (green) appears in axonal processes (vertical arrows) and cell bodies (horizontal arrows). DAPI is used as the counterstain (blue).
Product Details
APR-001-200UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
(CS)DPVATSSTLGLQENMRTS, corresponding to amino acid residues 382-399 of rat P2X1 receptor, Intracellular, C-terminus
Conjugate
Form
Lyophilized
Concentration
0.8 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 1% BSA
Contains
0.05% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
Target Information
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel with relatively high calcium permeability. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle, being responsible, for example, for sympathetic vasoconstriction in small arteries, arterioles and vas deferens. Mouse studies suggest that this receptor is essential for normal male reproductive function. It is possible that the development of selective antagonists for this receptor may provide an effective non-hormonal male contraceptive pill.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ATP receptor; P2X purinoceptor 1; P2X receptor, subunit 1; P2X1; P2X1 receptor; programmed cell death 3; Purinergic receptor; purinergic receptor P2X, ligand gated ion channel, 1; purinergic receptor P2X, ligand-gated ion channel, 1; purinergic receptor P2X1; RP-2 protein
Gene Aliases: AI323649; BB122383; P2RX1; P2x; P2X1; P2XMR; Pdcd3; RP-2
UniProt ID: (Human) P51575, (Rat) P47824, (Mouse) P51576
Entrez Gene ID: (Human) 5023, (Rat) 25505, (Mouse) 18436
serotonin secretion by platelet
regulation of vascular smooth muscle contraction
transport
ion transport
apoptotic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
signal transduction
insemination
blood coagulation
regulation of blood pressure
neuronal action potential
platelet activation
response to ATP
synaptic transmission, glutamatergic
purinergic nucleotide receptor signaling pathway
vasoconstriction
positive regulation of ion transport
ceramide biosynthetic process
protein homooligomerization
protein heterooligomerization
regulation of calcium ion transport
cation transmembrane transport
cation transport
regulation of smooth muscle contraction
response to organic substance
regulation of vasoconstriction
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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