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PADI2 Antibody (MA5-55788) in WB
Western blot analysis of PADI2 in 15 µg of AsPC-1. Sample was run on 6-18% SDS-PAGE under reducing conditions, blotted onto nitrocellulose membrane, and peroxidase conjugated goat anti-mouse IgG was used as the secondary antibody. PADI2 band was visualized using ECL Western Blotting Substrate. Incubation with primary PADI2 monoclonal antibody (Product # MA5-55788) at a dilution of 1 µg/mL was used.
Product Details
MA5-55788
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
K40045_12F1
Immunogen
Recombinant human PADI2 (immunogen range is 41-120).
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Dry ice (international)
Product Specific Information
Sequence of this protein is as follows: SLKHSEHVWV EVVRDGEAEE VATNGKQRWL LSPSTTLRVT MSQASTEASS DKVTVNYYDE EGSIPIDQAG LFLTAIEISL
Target Information
This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type II enzyme is the most widely expressed family member. Known substrates for this enzyme include myelin basic protein in the central nervous system and vimentin in skeletal muscle and macrophages. This enzyme is thought to play a role in the onset and progression of neurodegenerative human disorders, including Alzheimer disease and multiple sclerosis, and it has also been implicated in glaucoma pathogenesis. This gene exists in a cluster with four other paralogous genes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: PAD-H19; peptidyl arginine deiminase, type II; Peptidylarginine deiminase II; Protein-arginine deiminase type II; Protein-arginine deiminase type-2; RP1-37C10.6
Gene Aliases: KIAA0994; PAD-H19; PAD2; PADI2; PDI2
UniProt ID: (Human) Q9Y2J8
Entrez Gene ID: (Human) 11240
chromatin organization
regulation of chromatin disassembly
protein citrullination
substantia nigra development
intracellular estrogen receptor signaling pathway
histone H3-R26 citrullination
chromatin-mediated maintenance of transcription
negative regulation of chemokine-mediated signaling pathway
negative regulation of lymphocyte chemotaxis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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