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Product Details
PA5-86573
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide, corresponding to amino acids 281-330 of Human PAI-1.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2803343
Product Specific Information
Purity is > 95% by SDS-PAGE.
Target Information
PAI1 (plasminogen activator inhibitor 1) belongs to serine protease inhibitor superfamily, and is the principal inhibitor of tissue-type and urokinase-type plasminogen activators (tPA and uPA). Platelets are the main source of the circulating PAI11, but it is synthesized and secreted by many tissue and cell types, including fibroblasts, smooth muscle cells, endothelial cells, hepatocytes, and inflammatory cells. Expression of PAI11 can be regulated at the transcriptional level by many factors including growth factors, cytokines, hormones, inflammatory factors, glucose or lipid metabolites, vascular tone regulating factors, chemicals, and other environmental or physical factors. PAI1 is present at increased levels in various disease states, and has been linked to an increased occurrence of thrombosis in obesity, thrombophilia and the metabolic syndrome. Defects in PAI-1 are characterized by abnormal bleeding. PAI1 mediates inhibition of fibrinolysis by inhibiting the activity of plasminogen activator, and may promote neuronal survival. Other defects in PAI1 are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency). Alternatively spliced transcript variants encoding different isoforms of PAI1 have been found.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Endothelial plasminogen activator inhibitor; nexin, plasminogen activator inhibitor type 1; PAI; PAI-1; plas; Plasminogen activator inhibitor 1; plasminogen activator inhibitor, type I; Plasminogen activator inhibitor-1 precursor (PAI-1) (Endothelial plasminogen activator inhibitor) (PAI); serine (or cysteine) peptidase inhibitor, clade E, member 1; serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; serine (or cysteine) proteinase inhibitor, clade E, member 1; serine (or cysteine) proteinase inhibitor, member 1; Serpin E1; serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; SERPINE-1
Gene Aliases: PAI; PAI-1; PAI1; PAI1A; Pai1aa; Planh; PLANH1; RATPAI1A; SERPINE1
UniProt ID: (Human) P05121, (Rat) P20961
Entrez Gene ID: (Human) 5054, (Mouse) 18787, (Rat) 24617
chronological cell aging
angiogenesis
platelet degranulation
circadian rhythm
regulation of receptor activity
negative regulation of plasminogen activation
negative regulation of endopeptidase activity
negative regulation of smooth muscle cell migration
positive regulation of blood coagulation
negative regulation of blood coagulation
extracellular matrix organization
negative regulation of cell migration
positive regulation of interleukin-8 production
negative regulation of cell adhesion mediated by integrin
positive regulation of leukotriene production involved in inflammatory response
fibrinolysis
positive regulation of angiogenesis
positive regulation of transcription from RNA polymerase II promoter
positive regulation of receptor-mediated endocytosis
positive regulation of inflammatory response
defense response to Gram-negative bacterium
negative regulation of fibrinolysis
negative regulation of vascular wound healing
negative regulation of wound healing
cellular response to lipopolysaccharide
positive regulation of monocyte chemotaxis
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of smooth muscle cell-matrix adhesion
negative regulation of endothelial cell apoptotic process
female gonad development
negative regulation of peptidase activity
positive regulation of gene expression
negative regulation of gene expression
cellular response to drug
wound healing
regulation of cell proliferation
regulation of angiogenesis
positive regulation of fibroblast proliferation
positive regulation of coagulation
positive regulation of keratinocyte migration
cellular response to interleukin-1
cellular response to transforming growth factor beta stimulus
positive regulation of calcium ion import
response to reactive oxygen species
response to lipopolysaccharide
cellular response to insulin stimulus
response to cytokine
response to laminar fluid shear stress
cellular response to potassium ion
cellular response to platelet-derived growth factor stimulus
tissue regeneration
glucose homeostasis
response to starvation
response to estrogen
cellular response to fibroblast growth factor stimulus
mast cell activation
negative regulation of proteolysis
decidualization
response to hyperoxia
cellular response to hydrogen peroxide
response to epidermal growth factor
cellular response to metal ion
cellular response to gravity
cellular response to mechanical stimulus
cellular response to nicotine
cellular response to ATP
cellular response to cAMP
cellular response to cGMP
cellular response to glucose stimulus
cellular response to growth factor stimulus
cellular response to follicle-stimulating hormone stimulus
cellular response to glucagon stimulus
cellular response to low-density lipoprotein particle stimulus
cellular response to organic cyclic compound
cellular response to cycloheximide
cellular response to hypoxia
cellular response to dexamethasone stimulus
response to transforming growth factor beta
cellular response to nerve growth factor stimulus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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