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Product Details
PA5-92985
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 176-425 of human PAICS (NP_0010729921)
Conjugate
Form
Liquid
Concentration
2.64 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2806573
Product Specific Information
Immunogen sequence: LEKSWLPQNC TLVDMKIEFG VDVTTKEIVL ADVIDNDSWR LWPSGDRSQQ KDKQSYRDLK EVTPEGLQMV KKNFEWVAER VELLLKSESQ CRVVVLMGST SDLGHCEKIK KACGNFGIPC ELRVTSAHKG PDETLRIKAE YEGDGIPTVF VAVAGRSNGL GPVMSGNTAY PVISCPPLTP DWGVQDVWSS LRLPSGLGCS TVLSPEGSAQ FAAQIFGLSN HLVWSKLRAS ILNTWISLKQ ADKKIRECNL; Positive Samples: Jurkat, 293T, SW620, Raji, HeLa
Target Information
This gene encodes a bifunctional enzyme containing phosphoribosylaminoimidazole carboxylase activity in its N-terminal region and phosphoribosylaminoimidazole succinocarboxamide synthetase in its C-terminal region. It catalyzes steps 6 and 7 of purine biosynthesis. The gene is closely linked and divergently transcribed with a locus that encodes an enzyme in the same pathway, and transcription of the two genes is coordinately regulated. The human genome contains several pseudogenes of this gene. Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AIR carboxylase; Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase; multifunctional protein ADE2; multifunctional protein ADE2H1; PAICS; phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase; phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole succinocarboxamide synthetase; SAICAR synthetase
Gene Aliases: ADE2; ADE2H1; AIRC; PAICS; PAIS
UniProt ID: (Human) P22234, (Rat) P51583
Entrez Gene ID: (Human) 10606, (Rat) 140946
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