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Product Details
H00005058-M01
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
1E11
Immunogen
PAK1 (NP_002567, 191 a.a. approximately 280 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
See Label
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: APRPEHTKSV YTRSVIEPLP VTPTRDVATS PISPTENNTT PPDALTRNTE KQKKKPKMSD EEILEKLRSI VSVGDPKKKY TRFEKIGQGA
Target Information
PAK1 is a serine/threonine kinase that is a target for restenosis, cancer, and immunosuppression treatment. These proteins serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK1 regulates cell motility and morphology.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ADRB2; alpha pak; Alpha-PAK; EC 2.7.11.1; kinase PAK1; MGC130000; MGC130001; p21 protein (Cdc42/Rac)-activated kinase 1; p21-activated kinase 1; p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast); p21/Cdc42/Rac1-activated kinase 1 (yeast Ste20-related); p65-PAK; PAK 1; PAK-1; PAK1B; Serine/threonine-protein kinase PAK 1; STE20 homolog, yeast
Gene Aliases: PAK1; PAKalpha
UniProt ID: (Human) Q13153
Entrez Gene ID: (Human) 5058
MAPK cascade
mitotic cell cycle
response to hypoxia
positive regulation of protein phosphorylation
stimulatory C-type lectin receptor signaling pathway
protein phosphorylation
exocytosis
apoptotic process
axonogenesis
positive regulation of cell proliferation
positive regulation of cell migration
T cell costimulation
actin cytoskeleton reorganization
cellular response to insulin stimulus
positive regulation of peptidyl-serine phosphorylation
positive regulation of intracellular estrogen receptor signaling pathway
Fc-epsilon receptor signaling pathway
Fc-gamma receptor signaling pathway involved in phagocytosis
wound healing
positive regulation of JUN kinase activity
protein autophosphorylation
ephrin receptor signaling pathway
branching morphogenesis of an epithelial tube
neuron projection morphogenesis
T cell receptor signaling pathway
positive regulation of stress fiber assembly
negative regulation of cell proliferation involved in contact inhibition
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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