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Immunogen sequence: RLCGHSAFP HLRVLEATAR AGGRIRSERC FGGVVEVGAH WIHGPSRGNP VFQLAAEYGL LGEKELSQEN QLVETGGHVG LPSVSYASSG ASVSLQLVAE MATLFYGLID QTREFLHAAE TPVPSVGEYL KKEIGQHVAG WTEDEETRKL KLAVLNSFFN LECCVSGTHS MDLVALAPFG EYTVLPGLDC TFSKGYQGLT NCMMAALPED TVVFEKPVKT IHWNGSFQEA AFPGETFPVS VECEDGDRFP AHHVIVTVPL GFLREHLDTF FDPPLPAEKA EAIRKIGFGT NNKIFLEFEE PFWEPDCQLI QLVWEDTSPL EDAAPELQDA WFRKL (31-364 aa encoded by B C032778)
Flavoenzyme which catalyzes the oxidation of N(1)-acetylspermine to spermidine and is thus involved in the polyamine back-conversion (PubMed:12477380). Can also oxidize N(1)-acetylspermidine to putrescine. Substrate specificity: N(1)-acetylspermine = N(1)-acetylspermidine > N(1),N(12)-diacylspermine >> spermine. Does not oxidize spermidine. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs (PubMed:12477380). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: exo-N4-amino; Peroxisomal N(1)-acetyl-spermine/spermidine oxidase; peroxisomal N1-acetyl-spermine/spermidine oxidase; Polyamine oxidase; putative GTP-binding protein
Gene Aliases: 2410012F02Rik; AI118225; PAO; PAOX; UNQ1923/PRO4398
UniProt ID: (Human) Q6QHF9, (Mouse) Q8C0L6
Entrez Gene ID: (Human) 196743, (Mouse) 212503, (Rat) 293589
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