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Invitrogen
PAX2 Recombinant Rabbit Monoclonal Antibody (JJ082-08)
Advanced Verification
This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated.
Product Details
MA5-32432
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
JJ082-08
Immunogen
Recombinant protein within Human Pax2 aa 161-357
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
TBS, pH 7.4, with 40% Glycerol, 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2809710
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
Target Information
The pax genes are a family of transcription factors that are active in specific tissues during early embryonic development. Pax family members possess a DNA-binding domain encoded by the paired box. Because paired domain containing genes encode transcription factors, they are capable of executing a genetic program. Several pax genes have also been associated with developmental mutations including: pax-3, which is associated with Waardenburg syndrome, pax-6, which is associated with Aniridia, and pax-2, which is associated with Wilms tumor. During embryogenesis, Pax-2 is expressed in the developing kidney. In particular, the pax-2 gene is expressed in condensing metanephric mesenchyme and in early epithelial structures derived from mesenchyme; however, pax-2 mRNA and protein levels are rapidly down regulated as the tubular epithelium matures. Although Pax-2 is down regulated during renal epithelium maturation, Pax-2 expression persists in the undifferentiated epithelium of Wilms' tumors. Persistent expression of Pax-2 in Wilms' tumors occurs frequently and correlates with the proliferation of poorly differentiated epithelial cells in these tumors. Interestingly, expression of the Wilms' tumor suppresser protein, WT1, coincides with down-regulation of the pax-2 gene; thus, suggesting that WT1 can directly repress pax-2 transcription.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: paired box gene 2; paired box homeotic gene 2; Paired box protein Pax-2
Gene Aliases: FSGS7; PAPRS; PAX2
UniProt ID: (Human) Q02962
Entrez Gene ID: (Human) 5076, (Rat) 293992
core promoter proximal region sequence-specific DNA binding
DNA binding
protein binding
transcription factor binding
superoxide-generating NADPH oxidase activity
transcription regulatory region DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcription factor activity, sequence-specific DNA binding
sequence-specific DNA binding
C2H2 zinc finger domain binding
urogenital system development
branching involved in ureteric bud morphogenesis
cell fate determination
mesonephros development
neural tube closure
optic cup morphogenesis involved in camera-type eye development
mesenchymal to epithelial transition involved in metanephros morphogenesis
retinal pigment epithelium development
transcription, DNA-templated
transcription from RNA polymerase II promoter
axonogenesis
mesodermal cell fate specification
aging
visual perception
glial cell differentiation
optic nerve development
optic nerve morphogenesis
optic nerve structural organization
vestibulocochlear nerve formation
response to nutrient levels
regulation of metanephros size
ureter maturation
pronephric field specification
inner ear morphogenesis
camera-type eye development
negative regulation of apoptotic process
negative regulation of programmed cell death
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
protein kinase B signaling
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
negative regulation of cytolysis
positive regulation of transcription from RNA polymerase II promoter
pronephros development
brain morphogenesis
stem cell differentiation
positive regulation of epithelial cell proliferation
oxidation-reduction process
mesenchymal to epithelial transition
optic chiasma development
cellular response to hydrogen peroxide
cellular response to retinoic acid
cellular response to glucose stimulus
cellular response to epidermal growth factor stimulus
metanephric mesenchyme development
positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
metanephric mesenchymal cell differentiation
nephric duct formation
ureter development
metanephric collecting duct development
metanephric epithelium development
metanephric distal convoluted tubule development
metanephric nephron tubule formation
positive regulation of metanephric glomerulus development
negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis
regulation of metanephric nephron tubule epithelial cell differentiation
reactive oxygen species metabolic process
cochlea development
cochlea morphogenesis
positive regulation of branching involved in ureteric bud morphogenesis
negative regulation of mesenchymal cell apoptotic process involved in metanephros development
negative regulation of apoptotic process involved in metanephric collecting duct development
negative regulation of apoptotic process involved in metanephric nephron tubule development
negative regulation of reactive oxygen species metabolic process
positive regulation of metanephric DCT cell differentiation
positive regulation of optic nerve formation
negative regulation of transcription from RNA polymerase II promoter
metanephros development
ureteric bud development
kidney development
positive regulation of cell proliferation
pancreas development
regulation of apoptotic process
regulation of programmed cell death
animal organ development
paramesonephric duct development
cellular response to mechanical stimulus
renal system development
mesonephric tubule development
mesonephric tubule formation
mesonephric duct development
ureter morphogenesis
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