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PAX5 Antibody (MA5-42928) in IHC (P)
Immunohistochemistry analysis of PAX5 in paraffin-embedded human spleen. Samples were incubated with PAX5 Monoclonal antibody (Product # MA5-42928) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.
Product Details
MA5-42928
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
4I0X4
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 200-300 of human PAX5 (Q02548).
Conjugate
Form
Liquid
Concentration
0.38 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 0.05% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2912069
Product Specific Information
Positive test controls include: Raji.
Immunogen sequence: DEGIQESPVP NGHSLPGRDF LRKQMRGDLF TQQQLEVLDR VFERQHYSDI FTTTEPIKPE QTTEYSAMAS LAGGLDDMKA NLASPTPADI GSSVPGPQSY P
Target Information
PAX5 is a member of the paired box (PAX) family of transcription factors. The PAX proteins are important regulators in early development and alterations in the expression of their genes are thought to contribute to neoplastic transformation. PAX5 is the B-cell lineage specific activator protein (BSAP) that is expressed at early, but not late stages, of B-cell differentiation. Its expression has also been detected in developing CNS and testis, therefore, PAX5 may not only play an important role in B-cell differentiation, but also in neural development and spermatogenesis. Mutations in the gene can result in leukemia, acute lymphoblastic 3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: B-cell lineage specific activator; B-cell-specific transcription factor; BSAP; paired box homeotic gene 5; Paired box protein Pax-5; paired domain gene 5; transcription factor PAX 5
Gene Aliases: ALL3; BSAP; PAX5
UniProt ID: (Human) Q02548
Entrez Gene ID: (Human) 5079
negative regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
humoral immune response
multicellular organism development
spermatogenesis
aging
organ morphogenesis
lateral ventricle development
cerebral cortex development
adult behavior
skeletal muscle cell differentiation
positive regulation of transcription from RNA polymerase II promoter
embryonic cranial skeleton morphogenesis
negative regulation of histone H3-K9 methylation
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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