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Product Details
MA5-15657
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1C8
Immunogen
Purified recombinant fragment of human PAX6 expressed in E. Coli.
Conjugate
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
ascites
Contains
0.03% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_11006360
Product Specific Information
MA5-15657 targets PAX6 in indirect ELISA, FACS and WB applications and shows reactivity with Human samples.
The MA5-15657 immunogen is purified recombinant fragment of human PAX6 expressed in E. Coli.
.
MA5-15657 detects PAX6 which has a predicted molecular weight of approximately 46kDa.
Target Information
This gene encodes paired box gene 6, one of many human homologs of the Drosophila melanogaster gene prd. In addition to the hallmark feature of this gene family, a conserved paired box domain, the encoded protein also contains a homeo box domain. Both domains are known to bind DNA, and function as regulators of gene transcription. This gene is expressed in the developing nervous system, and in developing eyes. Mutations in this gene are known to cause ocular disorders such as aniridia and Peter's anomaly. Alternatively spliced transcript variants encoding either the same or different isoform have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Aniridia; Aniridia type II protein; Dickie's small eye; Keratitis; MGC17209; Oculorhombin; paired box gene 6; Paired Box Gene-6; paired box homeotic gene-6; Paired box protein Pax-6; small eye
Gene Aliases: 1500038E17Rik; AEY11; AN; AN2; D11S812E; Dey; FVH1; Gsfaey11; MGDA; Pax-6; PAX6; Sey; WAGR
UniProt ID: (Human) P26367, (Mouse) P63015
Entrez Gene ID: (Human) 5080, (Mouse) 18508
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II core promoter sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
ubiquitin-protein transferase activity
protein binding
transcription factor binding
protein kinase binding
ubiquitin protein ligase binding
histone acetyltransferase binding
co-SMAD binding
R-SMAD binding
HMG box domain binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
AT DNA binding
double-stranded DNA binding
sequence-specific DNA binding
transcription regulatory region DNA binding
negative regulation of transcription from RNA polymerase II promoter
establishment of mitotic spindle orientation
blood vessel development
eye development
cell fate determination
neuron migration
negative regulation of protein phosphorylation
positive regulation of neuroblast proliferation
lens development in camera-type eye
type B pancreatic cell differentiation
pancreatic A cell development
transcription from RNA polymerase II promoter
smoothened signaling pathway
axon guidance
central nervous system development
salivary gland morphogenesis
visual perception
response to wounding
regulation of asymmetric cell division
organ morphogenesis
dorsal/ventral axis specification
positive regulation of gene expression
protein ubiquitination
oligodendrocyte cell fate specification
cerebral cortex regionalization
forebrain anterior/posterior pattern specification
forebrain dorsal/ventral pattern formation
commitment of neuronal cell to specific neuron type in forebrain
forebrain-midbrain boundary formation
regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification
regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification
regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment
pituitary gland development
signal transduction involved in regulation of gene expression
keratinocyte differentiation
regulation of cell migration
positive regulation of epithelial cell differentiation
lacrimal gland development
protein localization to organelle
eye photoreceptor cell development
glucose homeostasis
negative regulation of neuron differentiation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
regulation of timing of cell differentiation
embryonic camera-type eye morphogenesis
neuron fate commitment
astrocyte differentiation
negative regulation of epithelial cell proliferation
negative regulation of neurogenesis
retina development in camera-type eye
iris morphogenesis
cornea development in camera-type eye
negative regulation of neural precursor cell proliferation
neural crest cell migration
epithelial cell development
pancreatic A cell differentiation
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
multicellular organism development
axonogenesis
brain development
negative regulation of cell proliferation
anterior/posterior pattern specification
dorsal/ventral pattern formation
regulation of gene expression
regulation of neuron projection development
pallium development
rhombomere morphogenesis
olfactory bulb development
telencephalon regionalization
interkinetic nuclear migration
cell differentiation
forebrain development
hindbrain development
positive regulation of cell fate specification
camera-type eye development
cell fate commitment
regulation of neuron differentiation
regulation of neurogenesis
neural precursor cell proliferation
positive regulation of glucagon secretion
insulin metabolic process
positive regulation of neuron migration
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