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NeoBiotechnologies
PAX8 Recombinant Rabbit Monoclonal Antibody (PAX8, 2774R)
Product Details
7849-RBM4-P1
Product Specifications
Species Reactivity
Dog,
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
PAX8, 2774R
Immunogen
Recombinant fragment (around aa 60-261) of human PAX8 protein
Conjugate
Form
Liquid
Concentration
200 µg/mL
Purification
Protein A/G
Storage buffer
PBS, pH 7.4, with 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
4° C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Immunohistochemistry (PFA fixed): incubate antibody for 30 min RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 degrees C followed by cooling at RT for 20 minutes.
Target Information
This gene encodes a member of the paired box family of transcription factors. Members of this gene family typically encode proteins that contain a paired box domain, an octapeptide, and a paired-type homeodomain. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas and atypical follicular thyroid adenomas. Alternatively spliced transcript variants encoding different isoforms have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: HGNC:8622; paired box gene 8; Paired box protein Pax-8; paired domain gene 8; Pax-8
Gene Aliases: PAX-8; PAX8
UniProt ID: (Human) Q06710
Entrez Gene ID: (Dog) 403927, (Human) 7849
transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
DNA binding
transcription factor activity, sequence-specific DNA binding
RNA polymerase II core promoter sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
thyroid-stimulating hormone receptor activity
protein binding
transcription regulatory region DNA binding
urogenital system development
branching involved in ureteric bud morphogenesis
mesonephros development
ventricular septum development
mesenchymal to epithelial transition involved in metanephros morphogenesis
transcription, DNA-templated
central nervous system development
negative regulation of cardiac muscle cell apoptotic process
thyroid gland development
pronephric field specification
inner ear morphogenesis
regulation of apoptotic process
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
pronephros development
cellular response to gonadotropin stimulus
otic vesicle development
positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
metanephric distal convoluted tubule development
metanephric comma-shaped body morphogenesis
metanephric S-shaped body morphogenesis
metanephric nephron tubule formation
negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis
regulation of metanephric nephron tubule epithelial cell differentiation
positive regulation of branching involved in ureteric bud morphogenesis
negative regulation of mesenchymal cell apoptotic process involved in metanephros development
negative regulation of apoptotic process involved in metanephric collecting duct development
negative regulation of apoptotic process involved in metanephric nephron tubule development
positive regulation of metanephric DCT cell differentiation
positive regulation of thyroid hormone generation
regulation of thyroid-stimulating hormone secretion
kidney development
transcription from RNA polymerase II promoter
sulfur compound metabolic process
anatomical structure morphogenesis
thyroid-stimulating hormone signaling pathway
metanephric epithelium development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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