Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MEGVAVVTAG SVGAAKTEGA AALPPPPPPP VSPPALTPAP AAGEEGPAPL SETGAPGCSG SRPPELEPER SLGRFRGRFE DEDEELEEEE ELEEEEEEEE EDMSHFSLRL EGGRQDSEDE EERLINLSEL TPYILCSICK GYLIDATTIT ECLHTFCKSC IVRHFYYSNR CPKCNIVVHQ TQPLYNISAN EGTGHFKPLE KKFVRVSGEA TIGHVEKFLR RKMGLDPACQ VDIICGDHLL EQYQTLREIR RAIGDAAMQD GLLVLHYGLV VSPLKIT
Polycomb group (PcG) proteins form multiprotein complexes that regulate expression patterns of developmental and cell proliferation genes. Several members of the PcG contain ring finger domains and are identified as a subclass of RING finger proteins. The RING-type zinc finger motif is present in a number of viral and eukaryotic proteins and is made of a conserved cysteine-rich domain that is able to bind two zinc atoms. Proteins that contain the RING-type zinc finger conserved domain are generally involved in the ubiquitination pathway of protein degradation. PCGF6 (polycomb group ring finger 6), also known as MBLR or RNF134, is a 350 amino acid nuclear protein that is ubiquitously expressed and contains one RING-type zinc finger. PCGF6 acts as a transcriptional repressor and regulates the level of histone H3K4Me3 by activating SmcY histone demethylase. PCGF6 exists as two alternatively spliced isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Mel18 and Bmi1-like RING finger; Mel18 and Bmi1-like RING finger protein; Polycomb group RING finger protein 6; RING finger protein 134
Gene Aliases: MBLR; PCGF6; RNF134
UniProt ID: (Human) Q9BYE7
Entrez Gene ID: (Human) 84108
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