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Product Details
PA5-110082
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 62-286 of human PCMT1 (NP_001238978.1).
Conjugate
Form
Liquid
Concentration
1.11 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2855493
Product Specific Information
Immunogen sequence: KSGGASHSEL IHNLRKNGII KTDKVFEVML ATDRSHYAKC NPYMDSPQSI GFQATISAPH MHAYALELLF DQLHEGAKAL DVGSGSGILT ACFARMVGCT GKVIGIDHIK ELVDDSVNNV RKDDPTLLSS GRVQLVVGDG RMGYAEEAPY DAIHVGAAAP VVPQALIDQL KPGGRLILPV GPAGGNQMLE QYDKLQDGSI KMKPLMGVIY VPLTDKEKQW SRDEL
Target Information
Three classes of protein carboxyl methyltransferases, distinguished by their methyl-acceptor substrate specificity, have been found in prokaryotic and eukaryotic cells. The type II enzyme catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to the free carboxyl groups of D-aspartyl and L-isoaspartyl residues. These methyl-accepting residues result from the spontaneous deamidation, isomerization, and racemization of normal L-aspartyl and L-asparaginyl residues and represent sites of covalent damage to aging proteins PCMT1 (EC 2.1.1.77) is a protein repair enzyme that initiates the conversion of abnormal D-aspartyl and L-isoaspartyl residues to the normal L-aspartyl form.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: L-isoaspartyl protein carboxyl methyltransferase; PIMT; protein carboxyl methyltransferase; Protein L-isoaspartyl/D-aspartyl methyltransferase; Protein-beta-aspartate methyltransferase; Protein-L-isoaspartate(D-aspartate) O-methyltransferase
Gene Aliases: C79501; PCM; PCMT1; PIMT
UniProt ID: (Human) P22061, (Rat) P22062, (Mouse) P23506
Entrez Gene ID: (Human) 5110, (Rat) 25604, (Mouse) 18537
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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