Proteintech

PCSK9 Polyclonal Antibody

PCSK9 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 13

PCSK9 Antibody (55206-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded human colon cancer tissue slide using (Product # 55206-1-AP) (PCSK9 antibody) at dilution of 1:500 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

Product Image Gallery

Product Details

55206-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 29 publications 29 publications

Immunohistochemistry (IHC)

View 12 publications 12 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:400

Immunocytochemistry (ICC/IF)

View 3 publications 3 publications

Immunoprecipitation (IP)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Peptide

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.31 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody is specific to PCSK9.

Target Information

PCSK9 is a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. This protein is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the endoplasmic reticulum. The protein may function as a proprotein convertase. The protein plays a role in cholesterol homeostasis and may have a role in the differentiation of cortical neurons.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Dendritic cell-derived exosomal miR-3064-5p inhibits SIRT6/PCSK9 to protect the blood-brain barrier after subarachnoid hemorrhage.

Journal of biochemical and molecular toxicology

Wang Y,Zhang L,Lv L,Zhou Z,Xi H

Thu Jun 01 00:00:00 EDT 2023

Dendritic cell-derived exosomal miR-3064-5p inhibits SIRT6/PCSK9 to protect the blood-brain barrier after subarachnoid hemorrhage.

Journal of biochemical and molecular toxicology

Wang Y,Zhang L,Lv L,Zhou Z,Xi H

Thu Jun 01 00:00:00 EDT 2023

Evolocumab loaded Bio-Liposomes for efficient atherosclerosis therapy.

Journal of nanobiotechnology

Li Z,Zhu H,Liu H,Liu D,Liu J,Jiang J,Zhang Y,Qin Z,Xu Y,Peng Y,Liu B,Long Y

Fri May 19 00:00:00 EDT 2023

Evolocumab loaded Bio-Liposomes for efficient atherosclerosis therapy.

Journal of nanobiotechnology

Li Z,Zhu H,Liu H,Liu D,Liu J,Jiang J,Zhang Y,Qin Z,Xu Y,Peng Y,Liu B,Long Y

Fri May 19 00:00:00 EDT 2023

Evolocumab loaded Bio-Liposomes for efficient atherosclerosis therapy.

Journal of nanobiotechnology

Li Z,Zhu H,Liu H,Liu D,Liu J,Jiang J,Zhang Y,Qin Z,Xu Y,Peng Y,Liu B,Long Y

Fri May 19 00:00:00 EDT 2023

Berberine is a potential alternative for metformin with good regulatory effect on lipids in treating metabolic diseases.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Guo HH,Shen HR,Wang LL,Luo ZG,Zhang JL,Zhang HJ,Gao TL,Han YX,Jiang JD

Sat Jul 01 00:00:00 EDT 2023

Pseurotin A Validation as a Metastatic Castration-Resistant Prostate Cancer Recurrence-Suppressing Lead via PCSK9-LDLR Axis Modulation.

Marine drugs

Abdelwahed KS,Siddique AB,Ebrahim HY,Qusa MH,Mudhish EA,Rad AH,Zerfaoui M,Abd Elmageed ZY,El Sayed KA

Tue Mar 28 00:00:00 EDT 2023

Pseurotin A Validation as a Metastatic Castration-Resistant Prostate Cancer Recurrence-Suppressing Lead via PCSK9-LDLR Axis Modulation.

Marine drugs

Abdelwahed KS,Siddique AB,Ebrahim HY,Qusa MH,Mudhish EA,Rad AH,Zerfaoui M,Abd Elmageed ZY,El Sayed KA

Tue Mar 28 00:00:00 EDT 2023

Early growth response 2 in the mPFC regulates mouse social and cooperative behaviors.

Lab animal

Zhang Y,Feng W,Wang Z,Pang Y,Jin Y,Chen S,Ding S,Wang T,Zou Y,Sun P,Chen Y,Feng H,Huang H,Sheng C,Xiao M

Wed Feb 01 00:00:00 EST 2023

Cholesterol-Lowering Activity of Vitisin A Is Mediated by Inhibiting Cholesterol Biosynthesis and Enhancing LDL Uptake in HepG2 Cells.

International journal of molecular sciences

Yuan Y,Zhu Y,Li Y,Li X,Jiao R,Bai W

Tue Feb 07 00:00:00 EST 2023

PCSK9 regulates the efficacy of immune checkpoint therapy in lung cancer.

Frontiers in immunology

Gao X,Yi L,Jiang C,Li S,Wang X,Yang B,Li W,Che N,Wang J,Zhang H,Zhang S

Mon Apr 10 00:00:00 EDT 2023

Testosterone Deficiency Promotes Hypercholesteremia and Attenuates Cholesterol Liver Uptake via AR/PCSK9/LDLR Pathways.

International journal of endocrinology

Yuefeng Y,Zhiqi L,Yi C,Keyu Z,Heng W,Yuying W,Ningjian W,Yuetian Y,Xinjie G,Yihao Z,Yingli L,Fangzhen X

Sat Jul 16 00:00:00 EDT 2022

Targeting PCSK9 in Liver Cancer Cells Triggers Metabolic Exhaustion and Cell Death by Ferroptosis.

Cells

Alannan M,Fatrouni H,Trézéguet V,Dittrich-Domergue F,Moreau P,Siegfried G,Liet B,Khatib AM,Grosset CF,Badran B,Fayyad-Kazan H,Merched AJ

Fri Dec 23 00:00:00 EST 2022

Rewiring Lipid Metabolism by Targeting PCSK9 and HMGCR to Treat Liver Cancer.

Cancers

Alannan M,Trézéguet V,Amoêdo ND,Rossignol R,Mahfouf W,Rezvani HR,Dittrich-Domergue F,Moreau P,Lacomme S,Gontier E,Grosset CF,Badran B,Fayyad-Kazan H,Merched AJ

Tue Dec 20 00:00:00 EST 2022

Lipid-lowering activity of metformin-soluble soybean polysaccharide nanoparticles.

Food & function

He H,Liu M,He R,Zhao W

Mon Oct 03 00:00:00 EDT 2022

Diverse Effects of Cilostazol on Proprotein Convertase Subtilisin/Kexin Type 9 between Obesity and Non-Obesity.

International journal of molecular sciences

Chen PW,Tseng SY,Chang HY,Lee CH,Chao TH

Mon Aug 29 00:00:00 EDT 2022

PCSK9 Suppresses M2-Like Tumor-Associated Macrophage Polarization by Regulating the Secretion of OX40L from Hepatocellular Carcinoma Cells.

Immunological investigations

Hu J,Zhang M,Gui L,Wan Q,Zhong J,Bai L,He M

Mon Aug 01 00:00:00 EDT 2022

PCSK9 Suppresses M2-Like Tumor-Associated Macrophage Polarization by Regulating the Secretion of OX40L from Hepatocellular Carcinoma Cells.

Immunological investigations

Hu J,Zhang M,Gui L,Wan Q,Zhong J,Bai L,He M

Mon Aug 01 00:00:00 EDT 2022

A multienzyme S-nitrosylation cascade regulates cholesterol homeostasis.

Cell reports

Stomberski CT,Venetos NM,Zhou HL,Qian Z,Collison BR,Field SJ,Premont RT,Stamler JS

Tue Oct 25 00:00:00 EDT 2022

A multienzyme S-nitrosylation cascade regulates cholesterol homeostasis.

Cell reports

Stomberski CT,Venetos NM,Zhou HL,Qian Z,Collison BR,Field SJ,Premont RT,Stamler JS

Tue Oct 25 00:00:00 EDT 2022

Renal Ischemia/Reperfusion Early Induces Myostatin and PCSK9 Expression in Rat Kidneys and HK-2 Cells.

International journal of molecular sciences

Barisione C,Verzola D,Garibaldi S,Ferrari PF,Garibotto G,Ameri P,Pane B,Spinella G,Pratesi G,Palombo D

Mon Sep 13 00:00:00 EDT 2021

Renal Ischemia/Reperfusion Early Induces Myostatin and PCSK9 Expression in Rat Kidneys and HK-2 Cells.

International journal of molecular sciences

Barisione C,Verzola D,Garibaldi S,Ferrari PF,Garibotto G,Ameri P,Pane B,Spinella G,Pratesi G,Palombo D

Mon Sep 13 00:00:00 EDT 2021

Renal Ischemia/Reperfusion Early Induces Myostatin and PCSK9 Expression in Rat Kidneys and HK-2 Cells.

International journal of molecular sciences

Barisione C,Verzola D,Garibaldi S,Ferrari PF,Garibotto G,Ameri P,Pane B,Spinella G,Pratesi G,Palombo D

Mon Sep 13 00:00:00 EDT 2021

Renal Ischemia/Reperfusion Early Induces Myostatin and PCSK9 Expression in Rat Kidneys and HK-2 Cells.

International journal of molecular sciences

Barisione C,Verzola D,Garibaldi S,Ferrari PF,Garibotto G,Ameri P,Pane B,Spinella G,Pratesi G,Palombo D

Mon Sep 13 00:00:00 EDT 2021

Renal Ischemia/Reperfusion Early Induces Myostatin and PCSK9 Expression in Rat Kidneys and HK-2 Cells.

International journal of molecular sciences

Barisione C,Verzola D,Garibaldi S,Ferrari PF,Garibotto G,Ameri P,Pane B,Spinella G,Pratesi G,Palombo D

Mon Sep 13 00:00:00 EDT 2021

Renal Ischemia/Reperfusion Early Induces Myostatin and PCSK9 Expression in Rat Kidneys and HK-2 Cells.

International journal of molecular sciences

Barisione C,Verzola D,Garibaldi S,Ferrari PF,Garibotto G,Ameri P,Pane B,Spinella G,Pratesi G,Palombo D

Mon Sep 13 00:00:00 EDT 2021

Purification, structural characterization, and PCSK9 secretion inhibitory effect of the novel alkali-extracted polysaccharide from Cordyceps militaris.

International journal of biological macromolecules

Wang J,Wang Y,Yang X,Lin P,Liu N,Li X,Zhang B,Guo S

Sat May 15 00:00:00 EDT 2021

The Cordyceps militaris-Derived Polysaccharide CM1 Alleviates Atherosclerosis in LDLR^(-/-) Mice by Improving Hyperlipidemia.

Frontiers in molecular biosciences

Yin F,Lin P,Yu WQ,Shen N,Li Y,Guo SD

Fri Dec 31 00:00:00 EST 2021

PCSK9 promotes tumor growth by inhibiting tumor cell apoptosis in hepatocellular carcinoma.

Experimental hematology & oncology

Zhang SZ,Zhu XD,Feng LH,Li XL,Liu XF,Sun HC,Tang ZY

Wed Mar 31 00:00:00 EDT 2021

Purification, characterization and anti-atherosclerotic effects of the polysaccharides from the fruiting body of Cordyceps militaris.

International journal of biological macromolecules

Yang X,Lin P,Wang J,Liu N,Yin F,Shen N,Guo S

Wed Jun 30 00:00:00 EDT 2021

PCSK9 mediates the oxidative low‑density lipoprotein‑induced pyroptosis of vascular endothelial cells via the UQCRC1/ROS pathway.

International journal of molecular medicine

Zeng J,Tao J,Xi L,Wang Z,Liu L

Thu Apr 01 00:00:00 EDT 2021

Plasma Purification Treatment Relieves the Damage of Hyperlipidemia to PBMCs.

Frontiers in cardiovascular medicine

Zhang XM,Gu YH,Deng H,Xu ZQ,Zhong ZY,Lyu XJ,Jin HM,Yang XH

Tue Jul 27 00:00:00 EDT 2021

Inhibition of PCSK9 potentiates immune checkpoint therapy for cancer.

Nature

Liu X,Bao X,Hu M,Chang H,Jiao M,Cheng J,Xie L,Huang Q,Li F,Li CY

Tue Dec 01 00:00:00 EST 2020

Prognostic Implication of a Metabolism-Associated Gene Signature in Lung Adenocarcinoma.

Molecular therapy oncolytics

He L,Chen J,Xu F,Li J,Li J

Wed Dec 16 00:00:00 EST 2020

Platycodin D enhances LDLR expression and LDL uptake via down-regulation of IDOL mRNA in hepatic cells.

Scientific reports

Choi YJ,Lee SJ,Kim HI,Lee HJ,Kang SJ,Kim TY,Cheon C,Ko SG

Mon Nov 16 00:00:00 EST 2020

Ascorbic acid enhances low-density lipoprotein receptor expression by suppressing proprotein convertase subtilisin/kexin 9 expression.

The Journal of biological chemistry

Wang D,Yang X,Chen Y,Gong K,Yu M,Gao Y,Wu X,Hu H,Liao C,Han J,Duan Y

Fri Nov 20 00:00:00 EST 2020

Hepatic cholesterol synthesis and lipoprotein levels impaired by dietary fructose and saturated fatty acids in mice: Insight on PCSK9 and CD36.

Nutrition (Burbank, Los Angeles County, Calif.)

Nergiz-Unal R,Ulug E,Kisioglu B,Tamer F,Bodur M,Yalcimin H,Yuruk AA

Wed Jun 23 00:00:00 EDT 2021

The marine-derived furanone reduces intracellular lipid accumulation in vitro by targeting LXRα and PPARα.

Journal of cellular and molecular medicine

Li T,Hu SM,Pang XY,Wang JF,Yin JY,Li FH,Wang J,Yang XQ,Xia B,Liu YH,Song WG,Guo SD

Sun Mar 01 00:00:00 EST 2020

Berberrubine and its analog, hydroxypropyl-berberrubine, regulate LDLR and PCSK9 expression via the ERK signal pathway to exert cholesterol-lowering effects in human hepatoma HepG2 cells.

Journal of cellular biochemistry

Cao S,Xu P,Yan J,Liu H,Liu L,Cheng L,Qiu F,Kang N

Fri Feb 01 00:00:00 EST 2019

Berberrubine and its analog, hydroxypropyl-berberrubine, regulate LDLR and PCSK9 expression via the ERK signal pathway to exert cholesterol-lowering effects in human hepatoma HepG2 cells.

Journal of cellular biochemistry

Cao S,Xu P,Yan J,Liu H,Liu L,Cheng L,Qiu F,Kang N

Fri Feb 01 00:00:00 EST 2019

Role of PCSK9 in lipid metabolic disorders and ovarian dysfunction in polycystic ovary syndrome.

Metabolism: clinical and experimental

Wang M,Zhao D,Xu L,Guo W,Nie L,Lei Y,Long Y,Liu M,Wang Y,Zhang X,Zhang L,Li H,Zhang J,Yuan D,Yue L

Wed May 01 00:00:00 EDT 2019

Role of PCSK9 in lipid metabolic disorders and ovarian dysfunction in polycystic ovary syndrome.

Metabolism: clinical and experimental

Wang M,Zhao D,Xu L,Guo W,Nie L,Lei Y,Long Y,Liu M,Wang Y,Zhang X,Zhang L,Li H,Zhang J,Yuan D,Yue L

Wed May 01 00:00:00 EDT 2019

The fucoidan from the brown seaweed Ascophyllum nodosum ameliorates atherosclerosis in apolipoprotein E-deficient mice.

Food & function

Yin J,Wang J,Li F,Yang Z,Yang X,Sun W,Xia B,Li T,Song W,Guo S

Thu Aug 01 00:00:00 EDT 2019

Fucoidan A2 from the Brown Seaweed Ascophyllum nodosum Lowers Lipid by Improving Reverse Cholesterol Transport in C57BL/6J Mice Fed a High-Fat Diet.

Journal of agricultural and food chemistry

Yang Z,Liu G,Wang Y,Yin J,Wang J,Xia B,Li T,Yang X,Hou P,Hu S,Song W,Guo S

Wed May 22 00:00:00 EDT 2019

Hydrogen sulfide inhibits PCSK9 expression through the PI3K/Akt‑SREBP‑2 signaling pathway to influence lipid metabolism in HepG2 cells.

International journal of molecular medicine

Xiao J,Bai XQ,Liao L,Zhou M,Peng J,Xiang Q,Ren Z,Wen HY,Jiang ZS,Tang ZH,Wang MM,Liu LS

Wed May 01 00:00:00 EDT 2019

Intracellular hepatitis B virus increases hepatic cholesterol deposition in alcoholic fatty liver via hepatitis B core protein.

Journal of lipid research

Wang Y,Wu T,Hu D,Weng X,Wang X,Chen PJ,Luo X,Wang H,Ning Q

Mon Jan 01 00:00:00 EST 2018

Intracellular hepatitis B virus increases hepatic cholesterol deposition in alcoholic fatty liver via hepatitis B core protein.

Journal of lipid research

Wang Y,Wu T,Hu D,Weng X,Wang X,Chen PJ,Luo X,Wang H,Ning Q

Mon Jan 01 00:00:00 EST 2018

Intracellular hepatitis B virus increases hepatic cholesterol deposition in alcoholic fatty liver via hepatitis B core protein.

Journal of lipid research

Wang Y,Wu T,Hu D,Weng X,Wang X,Chen PJ,Luo X,Wang H,Ning Q

Mon Jan 01 00:00:00 EST 2018

Intracellular hepatitis B virus increases hepatic cholesterol deposition in alcoholic fatty liver via hepatitis B core protein.

Journal of lipid research

Wang Y,Wu T,Hu D,Weng X,Wang X,Chen PJ,Luo X,Wang H,Ning Q

Mon Jan 01 00:00:00 EST 2018

PCSK9 Promotes oxLDL-Induced PC12 Cell Apoptosis Through the Bcl-2/Bax-Caspase 9/3 Signaling Pathway.

Journal of Alzheimer's disease : JAD

Liu LS,Bai XQ,Gao Y,Wu Q,Ren Z,Li Q,Pan LH,He NY,Peng J,Tang ZH

Fri Aug 25 00:00:00 EDT 2017

PCSK9 Promotes oxLDL-Induced PC12 Cell Apoptosis Through the Bcl-2/Bax-Caspase 9/3 Signaling Pathway.

Journal of Alzheimer's disease : JAD

Liu LS,Bai XQ,Gao Y,Wu Q,Ren Z,Li Q,Pan LH,He NY,Peng J,Tang ZH

Fri Aug 25 00:00:00 EDT 2017

Hyperlipidemia-induced apoptosis of hippocampal neurons in apoE(-/-) mice may be associated with increased PCSK9 expression.

Molecular medicine reports

Zhao XS,Wu Q,Peng J,Pan LH,Ren Z,Liu HT,Jiang ZS,Wang GX,Tang ZH,Liu LS

Wed Feb 01 00:00:00 EST 2017

Hyperlipidemia-induced apoptosis of hippocampal neurons in apoE(-/-) mice may be associated with increased PCSK9 expression.

Molecular medicine reports

Zhao XS,Wu Q,Peng J,Pan LH,Ren Z,Liu HT,Jiang ZS,Wang GX,Tang ZH,Liu LS

Wed Feb 01 00:00:00 EST 2017

Bioinformatics

Protein Aliases: convertase subtilisin; convertase subtilisin/kexin type 9 preproprotein; hypercholesterolemia; NARC-1; neural apoptosis regulated convertase 1; Neural apoptosis-regulated convertase 1; OTTHUMP00000009833; PC9; Proprotein convertase 9; proprotein convertase PC9; Proprotein convertase subtilisin/kexin type 9; Subtilisin/kexin-like protease PC9

View more View less

Gene Aliases: AI415265; AI747682; FH3; HCHOLA3; LDLCQ1; NARC-1; NARC1; PC9; PCSK9; PSEC0052

View more View less

UniProt ID: (Human) Q8NBP7, (Rat) P59996, (Mouse) Q80W65

View more View less

Entrez Gene ID: (Human) 255738, (Rat) 298296, (Mouse) 100102

View more View less

Function(s)

serine-type endopeptidase activity protein binding sodium channel inhibitor activity low-density lipoprotein particle binding receptor inhibitor activity apolipoprotein binding very-low-density lipoprotein particle binding apolipoprotein receptor binding protein self-association poly(A) RNA binding low-density lipoprotein particle receptor binding very-low-density lipoprotein particle receptor binding peptidase activity serine-type peptidase activity hydrolase activity serine protease

Process(es)

kidney development liver development negative regulation of receptor recycling positive regulation of receptor internalization triglyceride metabolic process phospholipid metabolic process apoptotic process lysosomal transport cholesterol metabolic process cellular response to starvation regulation of receptor activity negative regulation of low-density lipoprotein particle clearance protein autoprocessing neurogenesis neuron differentiation low-density lipoprotein particle receptor catabolic process positive regulation of low-density lipoprotein particle receptor catabolic process cellular response to insulin stimulus lipoprotein metabolic process cholesterol homeostasis regulation of neuron apoptotic process positive regulation of neuron apoptotic process negative regulation of receptor activity negative regulation of sodium ion transmembrane transporter activity proteolysis protein processing low-density lipoprotein receptor particle metabolic process regulation of low-density lipoprotein particle receptor catabolic process lipid metabolic process steroid metabolic process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more

PCSK9 Polyclonal Antibody

PCSK9 Antibody (55206-1-AP) in IHC (P)

Product Details

55206-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

We're here to help

Your items have has been added!