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OriGene
PCSK9 Monoclonal Antibody (OTI8E10), TrueMAB™
Advanced Verification
This Antibody was verified by Knockout to ensure that the antibody binds to the antigen stated.
FIGURE: 1 / 4
PCSK9 Antibody (TA811840) in WB
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PCSK9 (RC220000, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-PCSK9. Positive lysates LY403563 (100 µg) and LC403563 (20 µg) can be purchased separately from OriGene.
Product Details
TA811840
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI8E10
Immunogen
Human recombinant protein fragment corresponding to amino acids 153-692 of human PCSK9 produced in E.coli.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 1% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
PCSK9 is a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. This protein is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the endoplasmic reticulum. The protein may function as a proprotein convertase. The protein plays a role in cholesterol homeostasis and may have a role in the differentiation of cortical neurons.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: convertase subtilisin/kexin type 9 preproprotein; hypercholesterolemia; NARC-1; neural apoptosis regulated convertase 1; Neural apoptosis-regulated convertase 1; OTTHUMP00000009833; PC9; Proprotein convertase 9; Proprotein convertase subtilisin/kexin type 9; Subtilisin/kexin-like protease PC9
Gene Aliases: FH3; HCHOLA3; LDLCQ1; NARC-1; NARC1; PC9; PCSK9; PSEC0052
UniProt ID: (Human) Q8NBP7
Entrez Gene ID: (Human) 255738
serine-type endopeptidase activity
protein binding
sodium channel inhibitor activity
low-density lipoprotein particle binding
receptor inhibitor activity
apolipoprotein binding
very-low-density lipoprotein particle binding
apolipoprotein receptor binding
protein self-association
poly(A) RNA binding
low-density lipoprotein particle receptor binding
very-low-density lipoprotein particle receptor binding
serine protease
kidney development
liver development
negative regulation of receptor recycling
positive regulation of receptor internalization
triglyceride metabolic process
phospholipid metabolic process
apoptotic process
lysosomal transport
cholesterol metabolic process
cellular response to starvation
regulation of receptor activity
negative regulation of low-density lipoprotein particle clearance
protein autoprocessing
neurogenesis
neuron differentiation
low-density lipoprotein particle receptor catabolic process
positive regulation of low-density lipoprotein particle receptor catabolic process
cellular response to insulin stimulus
lipoprotein metabolic process
cholesterol homeostasis
regulation of neuron apoptotic process
positive regulation of neuron apoptotic process
negative regulation of receptor activity
negative regulation of sodium ion transmembrane transporter activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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