Proteintech

PD-ECGF Polyclonal Antibody

PD-ECGF Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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PD-ECGF Antibody (12383-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human breast cancer tissue slide using 12383-1-AP ( PD-ECGF antibody) at dilution of 1:200 (under 40x lens) heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

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Product Details

12383-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 4 publications 4 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Flow Cytometry (Flow)

Assay-dependent

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

PD-ECGF Fusion Protein Ag3052 (1-297 aa encoded by BC018160)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.21 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MAALMTPGT GAPPAPGDFS GEGSQGLPDP SPEPKQLPEL IRMKRDGGRL SEADIRGFVA AVVNGSAQGA QIGAMLMAIR LRGMDLEETS VLTQALAQSG QQLEWPEAWR QQLVDKHSTG GVGDKVSLVL APALAACGCK VPMISGRGLG HTGGTLDKLE SIPGFNVIQS PEQMQVLLDQ AGCCIVGQSE QLVPAEGILY AARDVTATVD SLPLITASIL SKKLVEGLSA LVVDVKFGGA AVFPNQEQAR ELAKTLVGVG ASLGLRVAAA LTAMDKPLGR CVGHALEVEE ALLCMDGA (1-297 aa encoded by BC018160)

Target Information

A platelet-derived endothelial growth factor (PD-ECGF), same as thymidine phosphorylase (TP) or gliostatin. In the presence of inorganic orthophosphate, it catalyses the reversible phospholytic cleavage of thymidine and deoxyuridine to their corresponding bases and 2-deoxyribose-1-phosphate. It is both chemotactic and mitogenic for endothelial cells and a non-heparin binding angiogenic factor present in platelets. It is also involved in transformation of fluoropyrimidines, cytotoxic agents used in the treatment of a variety of malignancies, into active cytotoxic metabolites.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

D-Penicillamine Reveals the Amelioration of Seizure-Induced Neuronal Injury via Inhibiting Aqp11-Dependent Ferroptosis.

Antioxidants (Basel, Switzerland)

Yang N,Zhang K,Guan QW,Wang ZJ,Chen KN,Mao XY

Fri Aug 19 00:00:00 EDT 2022

The proteomic characterization of the peritumor microenvironment in human hepatocellular carcinoma.

Oncogene

Gu Y,Guo Y,Gao N,Fang Y,Xu C,Hu G,Guo M,Ma Y,Zhang Y,Zhou J,Luo Y,Zhang H,Wen Q,Qiao H

Fri Apr 01 00:00:00 EDT 2022

Exploring the protective effects of schizandrol A in acute myocardial ischemia mice by comprehensive metabolomics profiling integrated with molecular mechanism studies.

Acta pharmacologica Sinica

Lai Q,Yuan GY,Wang H,Liu ZL,Kou JP,Yu BY,Li F

Sat Aug 01 00:00:00 EDT 2020

Exploring the protective effects of schizandrol A in acute myocardial ischemia mice by comprehensive metabolomics profiling integrated with molecular mechanism studies.

Acta pharmacologica Sinica

Lai Q,Yuan GY,Wang H,Liu ZL,Kou JP,Yu BY,Li F

Sat Aug 01 00:00:00 EDT 2020

Capecitabine reverses tumor escape from anti-VEGF through the eliminating CD11b^high/Gr1^high myeloid cells.

Oncotarget

Iwai T,Harada Y,Saeki H,Oki E,Maehara Y,Yonemitsu Y

Tue Apr 03 00:00:00 EDT 2018

Capecitabine reverses tumor escape from anti-VEGF through the eliminating CD11b^high/Gr1^high myeloid cells.

Oncotarget

Iwai T,Harada Y,Saeki H,Oki E,Maehara Y,Yonemitsu Y

Tue Apr 03 00:00:00 EDT 2018

Evaluation of [¹⁸F]Fluorothymidine as a Biomarker for Early Therapy Response in a Mouse Model of Colorectal Cancer.

Molecular imaging and biology

Rapic S,Vangestel C,Verhaeghe J,Thomae D,Pauwels P,Van den Wyngaert T,Staelens S,Stroobants S

Wed Feb 01 00:00:00 EST 2017

Evaluation of [¹⁸F]Fluorothymidine as a Biomarker for Early Therapy Response in a Mouse Model of Colorectal Cancer.

Molecular imaging and biology

Rapic S,Vangestel C,Verhaeghe J,Thomae D,Pauwels P,Van den Wyngaert T,Staelens S,Stroobants S

Wed Feb 01 00:00:00 EST 2017

4-Methylumbelliferone inhibits ovarian cancer growth by suppressing thymidine phosphorylase expression.

Journal of ovarian research

Tamura R,Yokoyama Y,Yoshida H,Imaizumi T,Mizunuma H

Sat Oct 11 00:00:00 EDT 2014

4-Methylumbelliferone inhibits ovarian cancer growth by suppressing thymidine phosphorylase expression.

Journal of ovarian research

Tamura R,Yokoyama Y,Yoshida H,Imaizumi T,Mizunuma H

Sat Oct 11 00:00:00 EDT 2014

Bioinformatics

Protein Aliases: Gliostatin; OTTHUMP00000196767; OTTHUMP00000196770; PD TP; PD-ECGF; Platelet-derived endothelial cell growth factor; TdRPase; Thymidine phosphorylase; TP

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Gene Aliases: ECGF; ECGF1; hPD-ECGF; MEDPS1; MNGIE; MTDPS1; PDECGF; TP; TYMP

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UniProt ID: (Human) P19971

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Entrez Gene ID: (Human) 1890

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Function(s)

phosphorylase activity platelet-derived growth factor receptor binding growth factor activity thymidine phosphorylase activity pyrimidine-nucleoside phosphorylase activity transferase activity, transferring pentosyl groups glycosyltransferase

Process(es)

mitochondrial genome maintenance angiogenesis pyrimidine nucleobase metabolic process pyrimidine nucleotide metabolic process DNA replication chemotaxis cell differentiation pyrimidine nucleoside salvage pyrimidine nucleoside catabolic process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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PD-ECGF Polyclonal Antibody

PD-ECGF Antibody (12383-1-AP) in IHC (P)

Product Details

12383-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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