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Product Details
66100-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1F1A11
Immunogen
PDCD4 Fusion Protein Ag19239 (169-469 aa encoded by BC026104)
Conjugate
Form
Liquid
Concentration
0.74 mg/mL
Purification
Protein G
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: TPIIQEYFE HGDTNEVAEM LRDLNLGEMK SGVPVLAVSL ALEGKASHRE MTSKLLSDLC GTVMSTTDVE KSFDKLLKDL PELALDTPRA PQLVGQFIAR AVGDGILCNT YIDSYKGTVD CVQARAALDK ATVLLSMSKG GKRKDSVWGS GGGQQSVNHL VKEIDMLLKE YLLSGDISEA EHCLKELEVP HFHHELVYEA IIMVLESTGE STFKMILDLL KSLWKSSTIT VDQMKRGYER IYNEIPDINL DVPHSYSVLE RFVEECFQAG IISKQLRDLC PSRGRKRFVS EGDGGRLKPE SY (169-469 aa encoded by BC026104)
Target Information
Apoptosis, also known as programmed cell death, plays major roles in development and normal tissue turnover in addition to tumor formation. During this process, the expression patterns of numerous genes are radically altered. One such gene is the programmed cell death protein 4 (PDCD4), whose expression was found to be upregulated in all cell lines following the onset of apoptosis. PDCD4 encodes a tumor suppressor protein whose expression is lost in carcinomas of breast, colon, lung and prostate. It can bind to and inhibit the helicase activity of the eukaryotic translation initiation factor 4A and inhibit the transactivation and transformation mediated by the transcription factor AP-1. The kinase Akt regulates PDCD4 by phosphorylation, decreasing the ability of PDCD4 to interfere with the transactivation of AP-1-responsive promoter by c-Jun. There are two known isoforms of PDCD4.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: MGC33046; MGC33047; Neoplastic transformation inhibitor protein; nuclear antigen H731; Nuclear antigen H731-like; Programmed cell death protein 4; Protein 197/15a; RP11-348N5.4
Gene Aliases: H731; PDCD4
UniProt ID: (Human) Q53EL6
Entrez Gene ID: (Human) 27250
apoptotic process
cell aging
positive regulation of smooth muscle cell apoptotic process
negative regulation of apoptotic process
negative regulation of JUN kinase activity
negative regulation of cell cycle
negative regulation of transcription, DNA-templated
negative regulation of myofibroblast differentiation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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