Invitrogen

PDE4D Polyclonal Antibody

1 Published Figure
1 Reference
View all (30) PDE4D antibodies
Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-79795

Applications
Tested Dilution
Publications

Western Blot (WB)

0.1-0.5 µg/mL
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Immunohistochemistry (Paraffin) (IHC (P))

0.5-1 µg/mL
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Immunohistochemistry (Frozen) (IHC (F))

0.5-1 µg/mL
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Immunocytochemistry (ICC/IF)

0.5-1 µg/mL
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Flow Cytometry (Flow)

1-3 µg/1x10^6 cells
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Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

E. coli-derived human PDE4D recombinant protein (Position: H466-Q709).
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

500 µg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS with 4mg trehalose

Contains

0.05mg sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

RRID

AB_2746910

Product Specific Information

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.

Target Information

This gene encodes one of four mammalian counterparts to the fruit fly 'dunce' gene. The encoded protein has 3',5'-cyclic-AMP phosphodiesterase activity and degrades cAMP, which acts as a signal transduction molecule in multiple cell types. This gene uses different promoters to generate multiple alternatively spliced transcript variants that encode functional proteins.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: 3',5'-cyclic-AMP phosphodiesterase 4D; cAMP-specific 3',5'-cyclic phosphodiesterase 4D; cAMP-specific phosphodiesterase 4D; cAMP-specific phosphodiesterase PDE4D; cAMP-specific phosphodiesterase PDE4D6; cAMP-specific phosphodiesterase splice variant PDE4D8; cyclic AMP specific phosphodiesterase PDE4D5A; DKFZp686M11213; DPDE3; dunce; FLJ97311; HGNC:8783; HS PDE4DN2; PDE43; PDE4D3; PDE4D7; Phosphodiesterase 4D cAMP-specific (dunce; phosphodiesterase 4D, cAMP specific; Phosphodiesterase 4D, cAMP-specific (dunce; phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila); testicular tissue protein Li 136

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Gene Aliases: 9630011N22Rik; ACRDYS2; DPDE3; HSPDE4D; PDE43; PDE4D; PDE4DN2; STRK1

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UniProt ID: (Human) Q08499, (Rat) P14270, (Mouse) Q01063

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Entrez Gene ID: (Human) 5144, (Rat) 24627, (Mouse) 238871

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Function(s)
3',5'-cyclic-nucleotide phosphodiesterase activity 3',5'-cyclic-AMP phosphodiesterase activity protein binding drug binding enzyme binding cAMP binding beta-2 adrenergic receptor binding ion channel binding metal ion binding ATPase binding scaffold protein binding cyclic-nucleotide phosphodiesterase activity SH3 domain binding protein domain specific binding ubiquitin protein ligase binding phosphoric diester hydrolase activity hydrolase activity phosphodiesterase
Process(es)
regulation of heart rate cAMP catabolic process smooth muscle contraction aging regulation of receptor activity regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum cAMP-mediated signaling neutrophil chemotaxis regulation of cAMP metabolic process positive regulation of interferon-gamma production positive regulation of interleukin-2 production positive regulation of interleukin-5 production negative regulation of peptidyl-serine phosphorylation multicellular organism growth negative regulation of heart contraction T cell receptor signaling pathway regulation of ryanodine-sensitive calcium-release channel activity establishment of endothelial barrier cellular response to lipopolysaccharide cellular response to epinephrine stimulus adrenergic receptor signaling pathway regulation of cardiac muscle cell contraction adrenergic receptor signaling pathway involved in positive regulation of heart rate regulation of cell communication by electrical coupling involved in cardiac conduction negative regulation of relaxation of cardiac muscle memory regulation of G-protein coupled receptor protein signaling pathway regulation of protein kinase A signaling positive regulation of smooth muscle cell migration lung development cellular protein complex assembly positive regulation of smooth muscle cell proliferation leukocyte migration cellular response to cAMP signal transduction
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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